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早期手术?对于股骨近端骨折患者,在入院后 48 小时内进行手术并不会增加院内死亡率。

Early surgery? In-house mortality after proximal femoral fractures does not increase for surgery up to 48 h after admission.

机构信息

Department of Trauma, Orthopedic, Plastic and Hand Surgery, University Hospital of Augsburg, Stenglinstrasse 2, 86156, Augsburg, Germany.

Zentrum für Unfallchirurgie und Orthopädie, Klinikum Ingolstadt GmbH, Krumenauerstraße 25, 85049, Ingolstadt, Germany.

出版信息

Aging Clin Exp Res. 2023 Jun;35(6):1231-1239. doi: 10.1007/s40520-023-02406-x. Epub 2023 May 4.

Abstract

PURPOSE

The economic cost linked to the increasing number of proximal femur fracture and their postoperative care is immense. Mortality rates are high. As early surgery is propagated to lower mortality and reduce complication rates, a 24-h target for surgery is requested. It was our aim to determine the cut-off for the time to surgery from admission and therefore establish a threshold at which the in-house mortality rate changes.

METHODS

A retrospective single-center cohort study was conducted including 1796 patients with an average age of 82.03 years treated operatively for a proximal femoral fracture between January 2016 and June 2020. A single treatment protocol was performed based on the type of anticoagulant, surgery, and renal function. Patient data, surgical procedure, time to surgery, complications, and mortality were assessed.

RESULTS

In-house mortality rate was 3.95%, and the overall complication rate was 22.7%. A prolonged length of hospital stay was linked to patient age and occurrence of complications. Mortality is influenced by age, number of comorbidities BMI, and postoperative complications of which the most relevant is pneumonia. The mean time to surgery for the entire cohort was 26.4 h. The investigation showed no significant difference in mortality rate among the two groups treated within 24 h and 24 to 48 h while comparing all patients treated within 48 h and after 48 h revealed a significant difference in mortality.

CONCLUSIONS

Age and number of comorbidities significantly influence mortality rates. Time to surgery is not the main factor influencing outcome after proximal femur fractures, and mortality rates do not differ for surgery up to 48 h after admission. Our data suggest that a 24-h target is not necessary, and the first 48 h may be used for optimizing preoperative patient status if necessary.

摘要

目的

与不断增加的股骨近端骨折数量及其术后护理相关的经济成本是巨大的。死亡率很高。由于早期手术可以降低死亡率和减少并发症发生率,因此要求 24 小时内完成手术。我们的目的是确定从入院到手术的时间截止值,并因此确定内部死亡率发生变化的阈值。

方法

进行了一项回顾性单中心队列研究,纳入了 1796 名平均年龄为 82.03 岁的患者,这些患者在 2016 年 1 月至 2020 年 6 月期间因股骨近端骨折接受了手术治疗。根据抗凝药物的类型、手术和肾功能,采用单一的治疗方案。评估了患者数据、手术程序、手术时间、并发症和死亡率。

结果

院内死亡率为 3.95%,总并发症发生率为 22.7%。住院时间延长与患者年龄和并发症发生有关。死亡率受年龄、合并症数量 BMI 以及术后并发症的影响,其中最相关的是肺炎。整个队列的平均手术时间为 26.4 小时。研究表明,在 24 小时内和 24 至 48 小时内治疗的两组患者的死亡率没有显著差异,而比较所有在 48 小时内和 48 小时后接受治疗的患者,死亡率存在显著差异。

结论

年龄和合并症数量对死亡率有显著影响。手术时间不是影响股骨近端骨折后结局的主要因素,入院后 48 小时内手术的死亡率没有差异。我们的数据表明,24 小时的目标没有必要,在前 48 小时内,如果需要,可以优化术前患者状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34eb/10200779/7b4d5f2f6d7a/40520_2023_2406_Fig1_HTML.jpg

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