Suppr超能文献

当前髋部骨折手术延迟指南是否过于严格?一项关于死亡率和经济学的单中心评估。

Are the current guidelines for surgical delay in hip fractures too rigid? A single center assessment of mortality and economics.

作者信息

Kempenaers Kristof, Van Calster Ben, Vandoren Cindy, Sermon An, Metsemakers Willem-Jan, Vanderschot Paul, Misselyn Dominique, Nijs Stefaan, Hoekstra Harm

机构信息

KU Leuven - University of Leuven, Faculty of Medicine, B-3000 Leuven, Belgium.

KU Leuven - University of Leuven, Department of Development and Regeneration, B-3000 Leuven, Belgium.

出版信息

Injury. 2018 Jun;49(6):1169-1175. doi: 10.1016/j.injury.2018.03.032. Epub 2018 Mar 27.

Abstract

PURPOSE

Controversy remains around acceptable surgical delay of acute hip fractures with current guidelines ranging from 24 to 48 h. Increasing healthcare costs force us to consider the economic burden as well. We aimed to evaluate the adjusted effect of surgical delay for hip fracture surgery on early mortality, healthcare costs and readmission rate. We hypothesized that shorter delays resulted in lower early mortality and costs.

METHODS

In this retrospective cohort study 2573 consecutive patients aged ≥50 years were included, who underwent surgery for acute hip fractures between 2009 and 2017. Main endpoints were thirty- and ninety-day mortality, total cost, and readmission rate. Multivariable regression included sex, age and ASA score as covariates.

RESULTS

Thirty-day mortality was 5% (n = 133), ninety-day mortality 12% (n = 304). Average total cost was €11960, dominated by hospitalization (59%) and honoraria (23%). Per 24 h delay, the adjusted odds ratio was 1.07 (95% CI 0.98-1.18) for thirty-day mortality, 1.12 (95% CI 1.04-1.19) for ninety-day mortality, and 0.99 (95% CI = 0.88-1.12) for readmission. Per 24 h delay, costs increased with 7% (95% CI 6-8%). For mortality, delay was a weaker predictor than sex, age, and ASA score. For costs, delay was the strongest predictor. We did not find clear cut-points for surgical delay after which mortality or costs increased abruptly.

CONCLUSIONS

Despite only modest associations with mortality, we observed a steady increase in healthcare costs when delaying surgery. Hence, a more pragmatic approach with surgery as soon as medically and organizationally possible seems justifiable over rigorous implementation of the current guidelines.

摘要

目的

目前关于急性髋部骨折可接受的手术延迟时间存在争议,指南给出的时间范围在24至48小时之间。不断增加的医疗成本迫使我们也要考虑经济负担。我们旨在评估髋部骨折手术延迟对早期死亡率、医疗成本和再入院率的校正影响。我们假设延迟时间越短,早期死亡率和成本就越低。

方法

在这项回顾性队列研究中,纳入了2009年至2017年间连续接受急性髋部骨折手术的2573例年龄≥50岁的患者。主要终点为术后30天和90天死亡率、总成本和再入院率。多变量回归将性别、年龄和美国麻醉医师协会(ASA)评分作为协变量。

结果

30天死亡率为5%(n = 133),90天死亡率为12%(n = 304)。平均总成本为11960欧元,其中住院费用(59%)和酬金(23%)占主导。每延迟24小时,30天死亡率的校正比值比为1.07(95%可信区间0.98 - 1.18),90天死亡率为1.12(95%可信区间1.04 - 1.19),再入院率为0.99(95%可信区间 = 0.88 - 1.12)。每延迟24小时,成本增加7%(95%可信区间6 - 8%)。对于死亡率,延迟是比性别、年龄和ASA评分更弱的预测因素。对于成本,延迟是最强的预测因素。我们没有发现手术延迟的明确切点,超过该切点死亡率或成本会突然增加。

结论

尽管与死亡率的关联不大,但我们观察到延迟手术时医疗成本稳步上升。因此,在医学和组织条件允许的情况下尽快进行手术,相较于严格执行当前指南,似乎更具合理性。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验