Jerry Michelle, Arcona Steve, McMorrow Donna, Schwartz Hana, Princic Nicole, Sasane Rahul
Merative, Ann Arbor, MI, USA.
Cerevel Therapeutics, Cambridge, MA, USA.
Clinicoecon Outcomes Res. 2023 Apr 27;15:309-319. doi: 10.2147/CEOR.S398509. eCollection 2023.
To examine work loss and indirect costs during the three-year periods prior to and following initial diagnosis of Parkinson's disease (PD) in patients and in spouses of PD patients, as well as direct costs of healthcare.
This is a retrospective, observational cohort study using the MarketScan Commercial and Health and Productivity Management databases.
A total of 286 employed PD patients and 153 employed spouses met all diagnostic and enrollment criteria for short-term disability (STD) analysis (PD Patient cohort and Caregiving Spouse cohort). The proportion of PD patients having a STD claim increased from roughly 5% and plateaued at around 12-14% starting in the year prior to first diagnosis of PD. The mean number of days lost from work due to STD per year increased from 1.4 days in the 3rd year prior to diagnosis to 8.6 days in the 3rd year after diagnosis (corresponding to an increase in indirect costs from $174 to $1104). STD use for spouses of patients with PD was lowest in the year after their spouses were diagnosed and then rose dramatically in the 2nd and 3rd years after the spouse's diagnosis. Total all-cause direct health-care costs increased during the years leading up to PD diagnosis and were highest in the years following diagnosis, with PD-related costs contributing ~20-30% of the total.
PD has both a significant direct and indirect financial burden on patients and their spouses when analyzed for 3 years before and after diagnosis.
研究帕金森病（PD）患者及其配偶在首次诊断PD之前和之后三年期间的工作损失和间接成本，以及医疗保健的直接成本。
这是一项回顾性观察队列研究，使用MarketScan商业、健康与生产力管理数据库。
共有286名在职PD患者和153名在职配偶符合短期残疾（STD）分析的所有诊断和纳入标准（PD患者队列和照料配偶队列）。患有STD索赔的PD患者比例从大约5%开始增加，并在首次诊断PD前一年开始稳定在12%-14%左右。每年因STD导致的平均误工天数从诊断前第3年的1.4天增加到诊断后第3年的8.6天（相应地，间接成本从174美元增加到1104美元）。PD患者配偶的STD使用率在其配偶被诊断后的第一年最低，然后在配偶诊断后的第2年和第3年急剧上升。在PD诊断前的几年中，全因直接医疗保健成本增加，在诊断后的几年中最高，与PD相关的成本占总成本的20%-30%。
在诊断前后3年进行分析时，PD对患者及其配偶有重大的直接和间接经济负担。
