Zhang Ping-Ping, He Xue-Ping, Tang Wen, Chen Han-Wei, Han Yuan-Yuan
Department of Radiology, Panyu Central Hospital, Guangzhou, China.
Department of Radiology, Guangdong Women and Children Hospital, Guangzhou, China.
Front Microbiol. 2023 Apr 17;14:1138962. doi: 10.3389/fmicb.2023.1138962. eCollection 2023.
Vaginal microbiota dysbiosis is closely related to diseases of the vagina and uterus. Uterine fibroids (UF) are the most common benign neoplasms of the uterus, and increased diversity in vaginal microbial of UF patients. High-intensity focused ultrasound (HIFU) is effective invasive treatment for fibroids in women who are not good surgical candidates. Whether HIFU of uterine fibroids will cause the change in vaginal microbiota has not been reported. We aimed to investigate the vaginal microbiota of UF patients with/without HIFU treatment using 16S rRNA gene sequencing.
Vaginal secretions were collected from 77 UF patients (pre-operative and post-operative) and were used for comparative composition, diversity, and richness analyses of microbial communities.
The microbial α-diversity was significantly lower in the vaginal of UF patients with HIFU treatment. The relative abundance of some pathogenic bacteria of UF patients with HIFU treatment were significantly decreased in the bacterial phylum and genus level. were found to be significantly upregulated as a biomarker in the HIFU treatment group in our study.
These findings might confirm the effectiveness of HIFU treatment from the point of view of microbiota.
阴道微生物群失调与阴道和子宫疾病密切相关。子宫肌瘤（UF）是子宫最常见的良性肿瘤，UF患者阴道微生物的多样性增加。高强度聚焦超声（HIFU）是对不适合手术的女性子宫肌瘤有效的侵入性治疗方法。子宫肌瘤的HIFU治疗是否会导致阴道微生物群的变化尚未见报道。我们旨在使用16S rRNA基因测序研究接受/未接受HIFU治疗的UF患者的阴道微生物群。
收集77例UF患者（术前和术后）的阴道分泌物，用于微生物群落的组成、多样性和丰富度的比较分析。
接受HIFU治疗的UF患者阴道中的微生物α多样性显著降低。接受HIFU治疗的UF患者的一些病原菌在细菌门和属水平上的相对丰度显著降低。在我们的研究中，被发现作为生物标志物在HIFU治疗组中显著上调。
这些发现可能从微生物群的角度证实了HIFU治疗的有效性。
