Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
BMC Microbiol. 2020 Apr 15;20(1):98. doi: 10.1186/s12866-020-01779-7.
To investigate the effect of transabdominal hysterectomy on the diversity of the intestinal flora in patients with uterine fibroids. Patients with uterine fibroids were selected from September 2018 to December 2018, in the Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, and stool specimens were collected from patients before and after surgery.
High-throughput sequencing of the 16S rRNA gene was used to detect the changes in microbial community structure and diversity, and the effects of total hysterectomy on the intestinal flora were further analyzed. Estrogen levels decreased after trans-abdominal hysterectomy. High-throughput sequencing showed that after abdominal hysterectomy, the abundance and diversity of the intestinal flora decreased. The abundance changes were mainly due to Proteobacteria, where their abundance increased.
Trans-abdominal hysterectomy changes the intestinal flora of the body by lowering the level of estrogen in the body, which reduces the diversity and abundance of the intestinal flora.
研究经腹全子宫切除术对子宫肌瘤患者肠道菌群多样性的影响。选取 2018 年 9 月至 2018 年 12 月在中国医科大学附属盛京医院妇产科就诊的子宫肌瘤患者，采集患者术前、术后粪便标本。
采用 16S rRNA 基因高通量测序检测微生物群落结构和多样性的变化，进一步分析经腹全子宫切除术对肠道菌群的影响。经腹全子宫切除术后雌激素水平降低。高通量测序显示，经腹全子宫切除术后肠道菌群丰度和多样性降低。丰度变化主要与变形菌门有关，其丰度增加。
经腹全子宫切除术通过降低体内雌激素水平改变机体肠道菌群，降低肠道菌群的多样性和丰度。
