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通过转基因斑马鱼研究某些心血管药物对血管生成的影响。

Investigation of the Effects of Some Cardiovascular Drugs on Angiogenesis by Transgenic Zebrafish.

机构信息

Department of Cardiovascular Disease, The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Department of Cardiovascular Disease, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200433, China.

出版信息

Mediators Inflamm. 2023 Apr 24;2023:1958046. doi: 10.1155/2023/1958046. eCollection 2023.

DOI:10.1155/2023/1958046
PMID:37138666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10151143/
Abstract

INTRODUCTION

Angiogenesis contributes to the pathophysiology of cardiovascular disease (CVD). Some cardiovascular drugs used in the treatment of CVD have an effect on the process of angiogenesis.

METHODS

Transgenic Tg (flk1: EGFP) zebrafish embryos were used to identify the effects of some cardiovascular drugs on angiogenesis during vertebral development . Zebrafish embryos at a one-cell stage or two-cell stage were cultured with embryo medium containing cardiovascular drugs at a final solvent concentration of 0.5% (V/V) dimethyl sulfoxide (DMSO) for 24 hours in 24-well plates.

RESULTS

We found that 6 drugs including isosorbide mononitrate, amlodipine, bisoprolol fumarate, carvedilol, irbesartan, and rosuvastatin calcium may affect angiogenesis by vascular endothelial growth factor (VEGF) signaling pathway.

CONCLUSION

These new findings of some cardiovascular drugs should improve the treatment of cardiovascular diseases.

摘要

简介

血管生成参与心血管疾病 (CVD) 的病理生理学。一些用于治疗 CVD 的心血管药物对血管生成过程有影响。

方法

使用转基因 Tg (flk1: EGFP) 斑马鱼胚胎来鉴定一些心血管药物在脊椎发育过程中对血管生成的影响。将处于单细胞期或双细胞期的斑马鱼胚胎在含有心血管药物的胚胎培养基中培养 24 小时，终溶剂浓度为 0.5% (V/V) 二甲基亚砜 (DMSO)，在 24 孔板中进行培养。

结果

我们发现包括单硝酸异山梨酯、氨氯地平、富马酸比索洛尔、卡维地洛、厄贝沙坦和瑞舒伐他汀钙在内的 6 种药物可能通过血管内皮生长因子 (VEGF) 信号通路影响血管生成。

结论

这些关于一些心血管药物的新发现，应该会改善心血管疾病的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/e3ccce0cc43d/MI2023-1958046.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/3714cdad56cf/MI2023-1958046.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/d6f923e2660e/MI2023-1958046.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/6460cd3969bf/MI2023-1958046.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/e3ccce0cc43d/MI2023-1958046.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/3714cdad56cf/MI2023-1958046.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/d6f923e2660e/MI2023-1958046.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/6460cd3969bf/MI2023-1958046.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070e/10151143/e3ccce0cc43d/MI2023-1958046.004.jpg

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