感染对癌症免疫检查点抑制剂治疗疗效的影响：一项荟萃分析。
Impact of infection on the efficacy of immune checkpoint inhibitors for cancer treatment: a meta-analysis.
机构信息
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Urology Research Center, Tehran University of Medical Science, Tehran, Iran.
出版信息
Immunotherapy. 2023 Jun;15(9):657-667. doi: 10.2217/imt-2022-0250. Epub 2023 May 4.
The present systematic review and meta-analysis was designed to assess the impact of infection on the efficacy of immune checkpoint inhibitors (ICIs). PubMed, Scopus, Web of Science and EMBASE databases were systematically searched up to 1 February 2023. Three studies comprising 263 patients treated with ICIs were included. The results of pooled analysis showed that infection was associated with reduced overall survival and progression-free survival. Furthermore, the rate of progressive disease after administration of ICIs was higher in -positive patients relative to -negative patients. infection status is a novel potential response biomarker for predicting the efficacy of ICIs in different cancers.
本系统评价和荟萃分析旨在评估感染对免疫检查点抑制剂（ICI）疗效的影响。系统检索了 PubMed、Scopus、Web of Science 和 EMBASE 数据库，截至 2023 年 2 月 1 日。纳入了三项包含 263 例接受 ICI 治疗患者的研究。汇总分析结果显示，感染与总生存期和无进展生存期降低相关。此外，与 - 阴性患者相比，- 阳性患者在接受 ICI 治疗后疾病进展的发生率更高。感染状态是一种新的潜在反应生物标志物，可预测不同癌症中 ICI 的疗效。
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