Ophthalmology Department, Faculty of Medicine, Menoufia University, Menoufia, Shebin El Kom, Egypt.
Ophthalmology Department, Faculty of Medicine, Kafrelshiekh University Hospital, Kafrelshiekh, Egypt.
Ir J Med Sci. 2023 Dec;192(6):3117-3123. doi: 10.1007/s11845-023-03373-y. Epub 2023 May 4.
Topical insulin can promote and accelerate corneal regeneration, even in eyes with serious comorbidities, and offers several benefits over other treatment options.
The aim of this study is to evaluate the effect of topical insulin in treatment of recurrent epithelial corneal erosion.
Patients with recurrent epithelial erosions were included in a prospective non-randomized hospital-based study, divided into two groups, one of them received persistent epithelial defects (PEDs) conventional treatment and the other received the same treatment with insulin eye drops 4 times/day. All patients were examined carefully by slit lamp. Patients during the 1st, 2nd, 3rd, and 4th weeks as well as after 2 months. Demographics, etiology, therapy, comorbidities, and the healing time of PED were performed.
Area shows significant improvement after 2 weeks (p = 0.006), 2 months (p = 0.046), and 3 months (p = 0.002) in group II (cornetears gel and topical insulin) as compared to group I (cornetears gel). The recurrence was statistically significant decreased with cornetears gel and topical insulin (group II) by 0.0%, as compared to cornetears gel (group I) by 3 patients (21.4%).
Topical insulin can promote corneal reepithelization in recurrent epithelial erosion and decreases recurrence in these cases. Other advantages include excellent tolerance, availability, and cost-effectiveness.
局部使用胰岛素可以促进和加速角膜再生，即使在有严重合并症的眼睛中也是如此，并且在其他治疗选择方面具有多种优势。
本研究旨在评估局部胰岛素治疗复发性上皮性角膜糜烂的效果。
将复发性上皮性糜烂患者纳入前瞻性非随机基于医院的研究中，分为两组，一组接受持续上皮缺损（PED）常规治疗，另一组接受相同治疗外加 4 次/天的胰岛素眼药水滴眼。所有患者均通过裂隙灯仔细检查。患者在第 1、2、3 和 4 周以及 2 个月后进行检查。记录患者的人口统计学、病因、治疗、合并症以及 PED 的愈合时间。
第 2 周（p=0.006）、第 2 个月（p=0.046）和第 3 个月（p=0.002），与第 1 组（角蛋白凝胶）相比，第 2 组（角蛋白凝胶联合局部胰岛素）的面积明显改善。与角蛋白凝胶（第 1 组）相比，角蛋白凝胶联合局部胰岛素（第 2 组）的复发率显著降低（0.0%），第 1 组有 3 例（21.4%）复发。
局部胰岛素可促进复发性上皮性糜烂的角膜再上皮化，并降低此类情况下的复发率。其他优点包括良好的耐受性、可及性和成本效益。
