Department of Radiation Oncology, The First Hospital of China Medical University, No.210, Baita 1st Street, Shenyang, 110167, PR China.
Eur J Oncol Nurs. 2023 Jun;64:102307. doi: 10.1016/j.ejon.2023.102307. Epub 2023 Mar 20.
Radiotherapy can negatively affect the pelvic floor function of patients with cervical cancer; however, the impact of different radiotherapy times and other related factors on pelvic floor function in cervical cancer survivors during radiotherapy remains unclear. We aimed to investigate the status of pelvic floor dysfunction (PFD) in cervical cancer survivors during radiotherapy and to analyze the factors influencing PFD.
In this cross-sectional study, a convenience sampling method was used to recruit cervical cancer survivors undergoing radiotherapy from January 2022 to July 2022 at a tertiary first-class hospital located in northeastern China. The Pelvic Floor Distress Inventory-Short Form 20 was used for participants' self-report of their PFD during radiotherapy.
Data from 120 cervical cancer survivors were included in this study. The results showed that the mean PFDI-20 total score was 32.69 ± 7.76. Multiple stepwise linear regression analysis showed that 56.9% of the variance in PFD was explained by age (β = 0.25, p < 0.001), body mass index (β = 0.32, p < 0.001), recurrence (β = 0.29, p < 0.001), number of radiotherapy sessions (β = 0.39, p < 0.001), and number of deliveries (β = 0.35, p < 0.001).
It is important to pay more attention to the PFD status of cervical cancer survivors receiving radiotherapy. Future therapeutic approaches should involve early identification of relevant risk factors early to provide patients with personalized care at different stages of radiotherapy for reducing their discomfort and improving their health-related quality of life.
放疗可能会对宫颈癌患者的盆底功能产生负面影响；然而，不同放疗时间以及其他相关因素对宫颈癌放疗后幸存者盆底功能的影响尚不清楚。本研究旨在探讨宫颈癌放疗后幸存者盆底功能障碍（PFD）的现状，并分析影响 PFD 的因素。
本横断面研究采用便利抽样法，于 2022 年 1 月至 7 月在东北地区一家三级甲等医院招募正在接受放疗的宫颈癌幸存者。采用盆底窘迫量表-简表（Pelvic Floor Distress Inventory-Short Form 20，PFDI-20）评估参与者放疗期间的 PFD。
本研究共纳入 120 例宫颈癌幸存者。结果显示，PFDI-20 总分的平均值为 32.69±7.76。多步线性回归分析显示，年龄（β=0.25，p<0.001）、体质量指数（β=0.32，p<0.001）、复发（β=0.29，p<0.001）、放疗次数（β=0.39，p<0.001）和分娩次数（β=0.35，p<0.001）可解释 PFD 的 56.9%。
放疗后宫颈癌幸存者的 PFD 状况值得关注。未来的治疗方法应包括早期识别相关危险因素，为患者提供个性化护理，在放疗的不同阶段减轻其不适，提高其健康相关生活质量。
