Roberts M H T, Rees H
Department of Physiology, University College Cardiff, Cardiff CF1 1XL U.K.
Pain. 1986 Apr;25(1):83-93. doi: 10.1016/0304-3959(86)90011-4.
Changes in the tail-flick latency to noxious heat were studied following electrical stimulation of the dorso-medial thalamus of the rat. Brief (15 sec), low intensity (35 microA) stimulation of the anterior pretectal nucleus caused no escape behavior or motor deficits but increased tail-flick latency for more than 45 min. Responses to non-noxious stimuli were enhanced but the animals were not hyperactive. The anterior pretectal nucleus does not receive retinal or accessory visual inputs like other parts of the pretectal complex but is known to receive axons from somatosensory cortex and project to the perirubral mesencephalic reticular formation and the periaqueductal gray (PAG). The antinociceptive effects of anterior pretectal stimulation were much longer lasting than those of PAG, less disrupting to motor performance and the stimulation was not aversive.
在对大鼠背内侧丘脑进行电刺激后，研究了其对有害热刺激的甩尾潜伏期变化。对前顶盖前核进行短暂（15秒）、低强度（35微安）刺激，未引起逃避行为或运动缺陷，但甩尾潜伏期增加超过45分钟。对非有害刺激的反应增强，但动物并未表现出多动。前顶盖前核不像顶盖前复合体的其他部分那样接受视网膜或辅助视觉输入，但已知其接受来自体感皮层的轴突，并投射到中脑红核周围网状结构和导水管周围灰质（PAG）。前顶盖前核刺激产生的抗伤害感受作用比PAG刺激持续时间长得多，对运动表现的干扰较小，且该刺激并无厌恶感。
