糖皮质激素对正常及关节炎大鼠血浆纤连蛋白水平的影响。

The effect of glucocorticoids on plasma fibronectin levels in normal and arthritic rats.

作者信息

Stecher V J, Connolly K M, Snyder B W

出版信息

Proc Soc Exp Biol Med. 1986 Jul;182(3):301-7. doi: 10.3181/00379727-182-42343.

Abstract

In vivo studies with normal and adjuvant-induced arthritic rats were undertaken in order to measure the effects of glucocorticoids on paw inflammation and plasma fibronectin (Fn) levels. Dexamethasone, methylprednisolone, and corticosterone all enhanced plasma Fn levels in normal animals. All drugs also significantly decreased inflammation in arthritic rats as measured by paw swelling. Of the three glucocorticoids, only corticosterone did not significantly enhance Fn levels in arthritic rats, possibly due to its lesser potency and narrow therapeutic window.

摘要

为了测定糖皮质激素对爪部炎症和血浆纤连蛋白（Fn）水平的影响，我们对正常大鼠和佐剂诱导的关节炎大鼠进行了体内研究。地塞米松、甲泼尼龙和皮质酮均能提高正常动物的血浆Fn水平。通过爪部肿胀测量发现，所有药物还能显著减轻关节炎大鼠的炎症。在这三种糖皮质激素中，只有皮质酮没有显著提高关节炎大鼠的Fn水平，这可能是由于其效力较低且治疗窗较窄。