Department of Clinical and Health Psychology, University of Florida, P.O. Box 100165, Gainesville, FL, 32610, USA.
Center for Pain Research and Behavioral Health, University of Florida, Gainesville, FL, USA.
Sci Rep. 2023 May 5;13(1):7340. doi: 10.1038/s41598-023-34546-5.
Acute alcohol intake produces subjective intoxication (SI) and response (SR; e.g., valanced stimulation and sedation), which has important implications for alcohol-related risk. Individuals who experience less SI may be more likely to engage in risky behaviors while drinking. Gray matter morphometry in brain regions underlying cognitive and affective processes may help to inform individual differences in subjective intoxication and response. The subjective effects of alcohol vary between limbs of the blood alcohol concentration (BAC) curve (i.e., whether BAC is rising or falling; acute tolerance). We examined the relationship between gray matter density (GMD) and SI/SR as a function of BAC limb. Healthy social drinkers (N = 89; 55 women) completed an alcohol challenge paradigm (target BAC = 0.08 g/dL) and structural magnetic resonance imaging (MRI). Participants completed measures of SR and SI on ascending and descending BAC limbs. Association between GMD and SI/SR on each limb were assessed using whole-brain, voxel-wise general linear models. GMD estimates were extracted from significant clusters. Differences in association of GMD and SI/SR between limbs were assessed using hierarchical regression. Significant associations of SI with GMD on the ascending limb were observed in the cerebellum. A significant association between SR and GMD on the descending limb were observed in the pre-motor cortex (BA6) and cerebellum. We identified common and unique associations among cerebellum and pre-central gyrus structures with SI and SR between BAC limbs. Functional imaging studies may further clarify unique dimensions of subjective alcohol effects linked to the observed structural associations.
急性饮酒会产生主观醉酒（SI）和反应（SR；例如，有价值的刺激和镇静），这对与酒精相关的风险有重要影响。那些经历较少 SI 的人在饮酒时可能更有可能从事冒险行为。大脑中与认知和情感过程相关的区域的灰质形态可能有助于解释主观醉酒和反应的个体差异。酒精的主观效应在血液酒精浓度（BAC）曲线的两个分支之间有所不同（即 BAC 是上升还是下降；急性耐受）。我们研究了灰质密度（GMD）与 SI/SR 之间的关系，作为 BAC 分支的函数。健康的社交饮酒者（N=89；55 名女性）完成了酒精挑战范式（目标 BAC=0.08 g/dL）和结构磁共振成像（MRI）。参与者在上升和下降的 BAC 支上完成了 SR 和 SI 的测量。使用全脑、体素水平的一般线性模型评估了 GMD 与每个支上的 SI/SR 之间的关系。从显著聚类中提取 GMD 估计值。使用分层回归评估 GMD 和 SI/SR 之间的关联在支之间的差异。在小脑中观察到 SI 与 GMD 之间在上升支上的显著关联。在运动前皮层（BA6）和小脑中观察到 SR 与 GMD 之间在下降支上的显著关联。我们确定了小脑和中央前回结构与 BAC 支之间的 SI 和 SR 之间的共同和独特关联。功能成像研究可能进一步阐明与观察到的结构关联相关的主观酒精效应的独特维度。
