Wade C E, Hunt M M
Pharmacol Biochem Behav. 1986 Apr;24(4):1129-32. doi: 10.1016/0091-3057(86)90466-1.
The effect of the opioid antagonist naloxone on drinking and the subsequent suppression of plasma vasopressin were evaluated in seven dogs following 24 hr of water deprivation. Each animal underwent an intravenous injection of vehicle as a control and a low (0.05 mg/kg) and high (1 mg/kg) dose of naloxone. Plasma vasopressin was significantly (p less than 0.05) increased from a control value of 4.6 +/- 1.9 microU/ml to 9.9 +/- 3.1 microU/ml after the high dose of naloxone. Fluid intake was not altered by naloxone; 42 +/- 6 ml/kg for the control, 45 +/- 8 ml/kg at the low dose, and 49 +/- 7 ml/kg for the high dose. Six minutes after the onset of drinking vasopressin was reduced by 48% for the control, 41% for the low dose and 45% for the high dose, with no significant difference among treatments. Thus, in dehydrated dogs naloxone presumably blocks endogenous opioids, elevates vasopressin following dehydration, but does not affect drinking behavior or the subsequent suppression of vasopressin after drinking.
在7只禁水24小时后的犬中，评估了阿片类拮抗剂纳洛酮对饮水及随后血浆血管加压素抑制作用的影响。每只动物静脉注射溶媒作为对照，并分别注射低剂量（0.05mg/kg）和高剂量（1mg/kg）的纳洛酮。高剂量纳洛酮注射后，血浆血管加压素从对照值4.6±1.9微单位/毫升显著（p＜0.05）升高至9.9±3.1微单位/毫升。纳洛酮未改变液体摄入量；对照为42±6毫升/千克，低剂量为45±8毫升/千克，高剂量为49±7毫升/千克。饮水开始6分钟后，对照的血管加压素降低48%，低剂量降低41%，高剂量降低45%，各处理之间无显著差异。因此，在脱水犬中，纳洛酮可能阻断内源性阿片类物质，在脱水后升高血管加压素，但不影响饮水行为或饮水后血管加压素的后续抑制作用。
