甲基偶氮甲醇诱导的小头畸形大鼠的选择性注意力受损。
Impaired selective attention in methylazoxymethanol-induced microencephalic rats.
作者信息
Mohammed A K, Jonsson G, Söderberg U, Archer T
出版信息
Pharmacol Biochem Behav. 1986 Apr;24(4):975-81. doi: 10.1016/0091-3057(86)90445-4.
Prenatal treatment of rats on gestation day 15 with methylazoxymethanol (MAM) caused forebrain microencephaly. Several behavioral tests were performed when the rats had reached an adult age. MAM treated rats were hyperactive, and were severely impaired in the acquisition of successive position reversal in a T-maze. The microencephalic rats failed also to demonstrate contextual control of latent inhibition (the stimulus preexposure effect) in taste-aversion conditioning. These results indicate that MAM treatment disrupts attentional processes and that this may account for the learning impairment.
在妊娠第15天用甲基氧化偶氮甲醇（MAM）对大鼠进行产前治疗会导致前脑小头畸形。当大鼠成年后进行了多项行为测试。接受MAM治疗的大鼠活动过度，并且在T迷宫中连续位置反转的习得方面严重受损。小头畸形的大鼠在味觉厌恶条件反射中也未能表现出对潜伏抑制（刺激预暴露效应）的情境控制。这些结果表明，MAM治疗会破坏注意力过程，这可能是学习障碍的原因。
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