Mohammed A K, Jonsson G, Sundström E, Minor B G, Söderberg U, Archer T
Brain Res. 1986 Dec;395(2):145-55. doi: 10.1016/s0006-8993(86)80194-9.
Prenatal treatment of rats on gestation day 15 with methylazoxymethanol (MAM) caused forebrain microencephaly. The behavioral analyses included measures of spontaneous motor activity and tests for cognitive deficits, and were performed when the rats had reached adult age. Female MAM-treated rats failed to demonstrate contextual control of latent inhibition, which confirms earlier findings with male rats. Male MAM-treated rats demonstrated a notable impairment of place navigation in a swim-maze, but showed as strong sensory preconditioning as the control animals. Biochemical analyses indicated considerable increases in catecholamine levels in the cerebral cortex, hippocampus and striatum. The cognitive deficits, characterised by the various conditioning (taste-aversion) and instrumental learning (swim-maze) tasks, suggested that the MAM rats are deficient in their capacity to attend selectively to the relevant stimulus in complex arrangements of the stimulus situation.
在妊娠第15天用甲基氧化偶氮甲醇（MAM）对大鼠进行产前治疗会导致前脑小头畸形。行为分析包括自发运动活动的测量和认知缺陷测试，在大鼠成年后进行。经MAM处理的雌性大鼠未能表现出对潜伏抑制的情境控制，这证实了早期对雄性大鼠的研究结果。经MAM处理的雄性大鼠在游泳迷宫中表现出明显的空间导航障碍，但与对照动物一样表现出强烈的感觉预适应。生化分析表明，大脑皮层、海马体和纹状体中的儿茶酚胺水平显著增加。以各种条件作用（味觉厌恶）和工具性学习（游泳迷宫）任务为特征的认知缺陷表明，MAM大鼠在复杂刺激情境中选择性关注相关刺激的能力存在缺陷。
