Schulz U, Löwe H, Blasig I E, Hergenröther D, Krause E G, Rohde E
Pharmazie. 1986 Mar;41(3):189-91.
The effect of Cordemcura, a new cardiotonic substance, was tested on retrograd perfused isolated rabbit hearts in comparison with equieffective doses of dopamine. The substances were applied continously via the perfusion medium in the following dosages: Cordemcura 3.34 X 10(-4) mol/l, 2.67 X 10(-3) mol/l; dopamine 3.9 X 10(-6) mol/l, 1.6 X 10(-5) mol/l). The effects of the substances were studied during normoxic and hypoxic perfusion. The heart rate was increased under normoxic perfusion of Cordemcura about 37.1% (3.34 X 10(-4) mol/l) and 17.9 (2.67 X 10(-3) mol/l). The oxygen consumption in relation to the performance of the hearts (contractility. heart rate) was increased by Cordemcura on 1.45 and 1.93 (3.34 X 10(-4) mol/l and 2.67 X 10(-3) mol/l) in the same way like by dopamine (1.30 and 2.66; 3.9 X 10(-6) mol/l and 1.6 X 10(-5) mol/l). The content of adenine nucleotides decreased in the hypoxic perfused hearts on nearly 20% of the control values. There was no difference between control, Cordemcura and dopamine treated hearts. Cordemcura increased the level of cAMP in the myocardium after 90 min of hypoxic perfusion in comparison with control hearts (control hearts 2.8 +/- 0.7 nmol/g protein; Cordemcura 4.7 +/- 0.8 nmol/g protein). In comparison to control hearts and dopamine treated hearts the hypoxic perfusion with Cordemcura resulted in a significant lower release of lactate dehydrogenase from the heart.
一种新型强心物质考地米松（Cordemcura）的作用，与等效剂量的多巴胺相比，在逆行灌注的离体兔心脏上进行了测试。这些物质通过灌注介质以以下剂量持续给药：考地米松3.34×10⁻⁴mol/L、2.67×10⁻³mol/L；多巴胺3.9×10⁻⁶mol/L、1.6×10⁻⁵mol/L。在常氧和低氧灌注期间研究了这些物质的作用。在考地米松常氧灌注下，心率增加约37.1%（3.34×10⁻⁴mol/L）和17.9（2.67×10⁻³mol/L）。考地米松使心脏（收缩性、心率）的氧消耗相对于其功能增加了1.45和1.93（3.34×10⁻⁴mol/L和2.67×10⁻³mol/L），与多巴胺（1.30和2.66；3.9×10⁻⁶mol/L和1.6×10⁻⁵mol/L）的情况相同。在低氧灌注的心脏中，腺嘌呤核苷酸含量下降至对照值的近20%。对照、考地米松和多巴胺处理的心脏之间没有差异。与对照心脏相比，考地米松在低氧灌注90分钟后增加了心肌中的环磷酸腺苷（cAMP）水平（对照心脏2.8±0.7nmol/g蛋白质；考地米松4.7±0.8nmol/g蛋白质）。与对照心脏和多巴胺处理的心脏相比，考地米松低氧灌注导致心脏中乳酸脱氢酶的释放显著降低。
