Hagen A, Frömmel B, Grünheid K, Lengwinat T, Stattmann A, Morgenstern E, Göres E
Pharmazie. 1986 Mar;41(3):207-8.
Side-effects of Cordemcura were verified in a relatively extensive repertoire of methods. Investigations of blood pressure activity, effect on heart frequency as well as PQ and QT times after continuous infusion, influence on diuresis and antidiuresis and behaviour to achieve results of a possible activity of the central nerve system were given priority. The proved vasodilatory qualities of Cordemcura become also evident in the rat blood pressure reduction due to higher dose as a result of i.v. injection. No hypotensive effect could be observed after oral administration of the drug. Heart frequency as well as PQ and QT times after i.v. infusion of 1 X 10(-4) mol/kg/min Cordemcura over a period of 15 min remained unchanged. Doses going far beyond therapeutically applied doses indicate a reduction of diuresis after oral administration of Cordemcura for rats. Only due to these high doses unspecific changes in the behaviour of rats and mice occurred. No specific central nerve system activity could be observed.
已通过相对广泛的一系列方法验证了考地米松的副作用。重点研究了血压活性、连续输注后对心率以及PQ和QT间期的影响、对利尿和抗利尿的影响以及对中枢神经系统可能活性的行为影响。考地米松已证实的血管舒张特性在静脉注射高剂量导致大鼠血压降低时也很明显。口服该药物后未观察到降压作用。在15分钟内以1×10⁻⁴摩尔/千克/分钟的速度静脉输注考地米松后，心率以及PQ和QT间期保持不变。远远超过治疗应用剂量的剂量表明，给大鼠口服考地米松后利尿减少。仅由于这些高剂量，大鼠和小鼠的行为出现了非特异性变化。未观察到特定的中枢神经系统活性。
