Murzi E, Hernandez L, Baptista T
Physiol Behav. 1986;36(5):829-34. doi: 10.1016/0031-9384(86)90438-5.
A hypothetical functional relationship between the feeding area of the lateral hypothalamus and the medullary and pontine taste areas was assessed in rats. Multiple electrodes were implanted in the lateral hypothalamus and the animals which exhibited eating upon electrical stimulation were selected. Then under pentobarbital anesthesia, the hypothalamus was electrically stimulated while unit activity of medullary and pontine taste areas was recorded. Electrical stimulation of the hypothalamus at sites which elicited eating affected 22% of gustatory neurons, 13% of proprioceptive neurons sensitive to oropharyngeal stimuli but only 0.2% of the remaining nongustatory neurons. Electrical stimulation at nonfeeding sites affected 3% of the gustatory neurons. The electrical stimulation of the hypothalamus had the same inhibitory or excitatory effect on a given gustatory neuron as the sapid stimulation of the tongue did. These results are discussed in terms of the taste pathways and their possible role in electrically elicited feeding.
在大鼠中评估了下丘脑外侧进食区域与延髓和脑桥味觉区域之间的一种假设性功能关系。将多个电极植入下丘脑外侧，选择那些在电刺激时表现出进食行为的动物。然后在戊巴比妥麻醉下，对下丘脑进行电刺激，同时记录延髓和脑桥味觉区域的单位活动。在下丘脑引发进食的部位进行电刺激，影响了22%的味觉神经元、13%对口咽刺激敏感的本体感觉神经元，但仅影响了其余非味觉神经元的0.2%。在非进食部位进行电刺激影响了3%的味觉神经元。下丘脑的电刺激对给定的味觉神经元产生的抑制或兴奋作用与舌部味觉刺激产生的作用相同。根据味觉通路及其在电诱发进食中可能发挥的作用对这些结果进行了讨论。
