Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.
Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Anhui Public Health Clinical Center, Hefei, China.
Biochem Pharmacol. 2023 Jun;212:115580. doi: 10.1016/j.bcp.2023.115580. Epub 2023 May 5.
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a class of non-coding RNA with a circular structure that participate in a series of important pathophysiological processes of OA, especially its ceRNA mechanisms, and play an important role in OA. CircRNAs may be potential biomarkers for the diagnosis and prognosis of OA. Additionally, differentially expressed circRNAs were found in patients with OA, indicating that circRNAs are involved in the pathogenesis of OA. Experiments have shown that the intra-articular injection of modified circRNAs can effectively relieve OA. Exosomal circRNAs and methylated circRNAs also provide new ideas for the treatment of OA. Clarifying the important roles of circRNAs in OA will deepen people's understanding of the pathogenesis of OA. CircRNAs may be developed as new biomarkers or drug targets for the diagnosis of OA and provide new methods for the treatment of OA.
骨关节炎（OA）是一种与年龄相关的关节疾病，具有慢性炎症、进行性关节软骨破坏和软骨下骨硬化。CircRNAs（circRNAs）是一类具有环状结构的非编码 RNA，参与 OA 的一系列重要病理生理过程，特别是其 ceRNA 机制，并在 OA 中发挥重要作用。CircRNAs 可能是 OA 诊断和预后的潜在生物标志物。此外，在 OA 患者中发现了差异表达的 circRNAs，表明 circRNAs 参与了 OA 的发病机制。实验表明，关节内注射修饰的 circRNAs 可以有效缓解 OA。外泌体 circRNAs 和甲基化 circRNAs 也为 OA 的治疗提供了新的思路。阐明 circRNAs 在 OA 中的重要作用将加深人们对 OA 发病机制的理解。CircRNAs 可能被开发为 OA 诊断的新生物标志物或药物靶点，并为 OA 的治疗提供新方法。
