Department of Biobehavioral Health, The Pennsylvania State University, Penn State University, University Park, PA, USA.
Pharmacol Res. 2023 Jun;192:106741. doi: 10.1016/j.phrs.2023.106741. Epub 2023 May 5.
Tobacco and nicotine use are associated with disease susceptibility and progression. Health challenges associated with nicotine and smoking include developmental delays, addiction, mental health and behavioral changes, lung disease, cardiovascular disease, endocrine disorders, diabetes, immune system changes, and cancer. Increasing evidence suggests that nicotine-associated epigenetic changes may mediate or moderate the development and progression of a myriad of negative health outcomes. In addition, nicotine exposure may confer increased lifelong susceptibility to disease and mental health challenges through alteration of epigenetic signaling. This review examines the relationship between nicotine exposure (and smoking), epigenetic changes, and maladaptive outcomes that include developmental disorders, addiction, mental health challenges, pulmonary disease, cardiovascular disease, endocrine disorders, diabetes, immune system changes, and cancer. Overall, findings support the contention that nicotine (or smoking) associated altered epigenetic signaling is a contributing factor to disease and health challenges.
烟草和尼古丁的使用与疾病易感性和进展有关。与尼古丁和吸烟相关的健康挑战包括发育迟缓、成瘾、心理健康和行为改变、肺部疾病、心血管疾病、内分泌紊乱、糖尿病、免疫系统变化和癌症。越来越多的证据表明，尼古丁相关的表观遗传变化可能介导或调节多种负面健康结果的发展和进展。此外，尼古丁暴露可能通过改变表观遗传信号而增加对疾病和心理健康挑战的终身易感性。本综述探讨了尼古丁暴露（和吸烟）、表观遗传变化与发育障碍、成瘾、心理健康挑战、肺部疾病、心血管疾病、内分泌紊乱、糖尿病、免疫系统变化和癌症等不良后果之间的关系。总的来说，研究结果支持这样一种观点，即尼古丁（或吸烟）相关的表观遗传信号改变是导致疾病和健康挑战的一个因素。
