Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9119, USA.
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9119, USA; Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9119, USA.
Psychiatr Clin North Am. 2023 Jun;46(2):247-259. doi: 10.1016/j.psc.2023.02.011. Epub 2023 Mar 27.
Major depressive disorder is a chronic and recurrent illness that affects 20% of adults during their lifetime and is one of the leading causes of suicide in the United States. A systematic measurement-based care approach is the essential first step in the diagnosis and management of treatment-resistant depression (TRD) by promptly identifying individuals with depression and avoiding delays in treatment initiation. As comorbidities may be associated with poorer outcomes to commonly used antidepressants and increase risk of drug-drug interactions, their recognition and treatment is an essential component of management of TRD.
重度抑郁症是一种慢性且反复发作的疾病，终生中有 20%的成年人会受到影响，它也是美国导致自杀的主要原因之一。通过及时识别抑郁症患者并避免治疗启动的延迟，系统的基于测量的护理方法是诊断和管理治疗抵抗性抑郁症（TRD）的基本第一步。由于共病可能与常用抗抑郁药的疗效较差相关，并增加药物相互作用的风险，因此识别和治疗共病是 TRD 管理的重要组成部分。
