Department of Psychology and Neuroscience, 1701 North 13th Street, Temple University, Philadelphia, PA 19122, USA.
Depression and Anxiety Center for Discovery and Treatment, 1399 Park Avenue, 2nd Floor, New York, NY 10029.
Psychiatr Clin North Am. 2023 Jun;46(2):391-401. doi: 10.1016/j.psc.2023.02.009. Epub 2023 Mar 25.
Increased awareness of the growing disease burden of treatment resistant depression (TRD), in combination with technological advances in MRI, affords the unique opportunity to research biomarkers that characterize TRD. We provide a narrative review of MRI studies investigating brain features associated with treatment-resistance and treatment outcome in those with TRD. Despite heterogeneity in methods and outcomes, relatively consistent findings include reduced gray matter volume in cortical regions and reduced white matter structural integrity in those with TRD. Alterations in resting state functional connectivity of the default mode network were also found. Larger studies with prospective designs are warranted.
人们对治疗抵抗性抑郁症（TRD）不断增加的疾病负担的认识不断提高，再加上 MRI 技术的进步，为研究能够描述 TRD 的生物标志物提供了独特的机会。我们对研究 TRD 患者的治疗抵抗和治疗结果相关的大脑特征的 MRI 研究进行了叙述性综述。尽管方法和结果存在异质性，但相对一致的发现包括：TRD 患者皮质区域的灰质体积减少和白质结构完整性降低。还发现静息状态默认模式网络的功能连接发生了改变。需要进行前瞻性设计的更大规模研究。
