Department of Pathology & Laboratory Medicine, BC Cancer, 600 West 10th Avenue, Vancouver, BC, V5Z 4E6 Canada.
Surg Pathol Clin. 2023 Jun;16(2):433-442. doi: 10.1016/j.path.2023.01.010. Epub 2023 Mar 15.
Lymphoma is a clinically and biologically heterogeneous disease. Next-generation sequencing (NGS) has expanded our understanding of this heterogeneity at the genetic level, refining disease classification, defining new entities, and providing additional information that can be used in diagnosis and management. This review highlights some of the NGS findings in lymphoma and how they can be used as genetic biomarkers to aid diagnosis and prognosis and guide therapy.
淋巴瘤是一种临床和生物学上具有异质性的疾病。下一代测序（NGS）在遗传水平上扩展了我们对这种异质性的理解，完善了疾病分类，定义了新的实体，并提供了可用于诊断和管理的其他信息。本文重点介绍了淋巴瘤的一些 NGS 发现，以及它们如何作为遗传生物标志物用于辅助诊断和预后，并指导治疗。
