Roediger W E, Deakin E J, Radcliffe B C, Nance S
Q J Exp Physiol. 1986 Apr;71(2):195-204. doi: 10.1113/expphysiol.1986.sp002978.
The regulatory functions of anions in colonic absorption of sodium are unknown. Absorption of sodium ions was assessed with chloride, butyrate, nitrite, sulphate and oxalate anions in segments of proximal/distal colon and in defunctioned colon. Efficiency of sodium absorption was related to availability of CO2 in mucosal cells: CO2 availability was enhanced (P less than 0.01) by sodium nitrite or diminished (P less than 0.01) in defunctioned colon. Sodium nitrite stimulated absorption of sodium in the distal colon where bicarbonate secretion predominated and n-butyrate stimulated absorption of sodium in the proximal colon where hydrogen ion secretion predominated. Sodium absorption was very significantly diminished (P less than 0.01) in defunctioned colon. Results indicate that sodium absorption in the colon is both a double anion exchange system as well as cation/anion co-transport. Anions act differently on sodium absorption along the length of the colon and prolonged lack of anions plays a part in sodium malabsorption of the defunctioned colon.
阴离子在结肠钠吸收中的调节功能尚不清楚。在近端/远端结肠段以及失功结肠中，用氯离子、丁酸盐、亚硝酸盐、硫酸盐和草酸盐阴离子评估钠离子的吸收情况。钠吸收效率与黏膜细胞中二氧化碳的可用性有关：亚硝酸钠可提高二氧化碳可用性（P<0.01），而在失功结肠中二氧化碳可用性降低（P<0.01）。亚硝酸钠刺激以碳酸氢盐分泌为主的远端结肠中的钠吸收，正丁酸盐刺激以氢离子分泌为主的近端结肠中的钠吸收。失功结肠中的钠吸收非常显著地减少（P<0.01）。结果表明，结肠中的钠吸收既是一个双阴离子交换系统，也是阳离子/阴离子协同转运过程。阴离子在结肠全长上对钠吸收的作用不同，长期缺乏阴离子在失功结肠的钠吸收不良中起作用。
