Roediger W E, Rae D A
Br J Surg. 1982 Jan;69(1):23-5. doi: 10.1002/bjs.1800690108.
Sodium and water absorption were measured in defunctioned loops of colon of dogs either in the presence or in the absence of the bacterial fatty acid, n-butyrate. In freshly defunctioned colonic loops n-butyrate enhanced sodium absorption twofold (P less than 0.05) and promoted sodium absorption for 48 h. In the absence of n-butyrate, defunctioned loops lost the ability to absorb sodium and water within 48 h. Pre-treatment of colonic loops with fatty acids for 3 h significantly diminished (P less than 0.05) sodium and water losses into the colonic lumen compared with loops pre-treated with saline only. Butyrate was absorbed at a steady rate even when no sodium was absorbed. Results suggest that fatty acids act on the colonic mucosa to exert a trophic effect on absorption of sodium. This trophic effect determines the efficiency of absorption of ions and could have clinical implications in the genesis of postoperative diarrhoea.
在有或没有细菌脂肪酸正丁酸存在的情况下，对犬失功结肠肠袢的钠和水吸收进行了测量。在新鲜失功的结肠肠袢中，正丁酸使钠吸收增加了两倍（P<0.05），并促进钠吸收达48小时。在没有正丁酸的情况下，失功肠袢在48小时内失去了吸收钠和水的能力。与仅用盐水预处理的肠袢相比，用脂肪酸对结肠肠袢进行3小时预处理可显著减少（P<0.05）钠和水向结肠腔的流失。即使在不吸收钠的情况下，丁酸也以稳定的速率被吸收。结果表明，脂肪酸作用于结肠黏膜，对钠的吸收产生营养作用。这种营养作用决定了离子吸收的效率，并且可能对术后腹泻的发生具有临床意义。
