Department of Internal Medicine, Jackson Memorial Hospital / University of Miami Health System, FL, USA.
The Population Registry of Cancer of the Metropolitan Area of Bucaramanga, Universidad Autónoma de Bucaramanga, Colombia.
Cancer Epidemiol. 2023 Aug;85:102375. doi: 10.1016/j.canep.2023.102375. Epub 2023 May 5.
Cervical cancer is still an important cause of death in countries like Colombia. We aimed to determine whether socioeconomic status of residential address (SES) and type of health insurance affiliation (HIA) might be associated with cervical cancer survival among women in Bucaramanga, Colombia. All patients residing in the Bucaramanga Metropolitan Area diagnosed with invasive cervical cancer (ICD-0-3 codes C53.X) between 2008 and 2016 (n = 725) were identified through the population-based cancer registry, with 700 women having follow-up data for >5 years (date of study closure: Dec 31, 2021), yielding an overall 5-year survival estimate (95 % CI) of 56.4 % (52.7 - 60.0 %). KM estimates of 5-year overall survival were obtained to assess differences in cervical cancer survival by SES and HIA. Multivariable Cox-proportional hazards modeling was also conducted, including interaction effects between SES and HIA. Five-year overall survival was lower when comparing low vs. high SES (41.9 % vs 57.9 %, p < 0.0001) and subsidized vs. contributive HIA (45.1 % vs 63.0 %, p < 0.0001). Multivariable Cox modeling showed increased hazard ratios (HR) of death for low vs. high SES (HR = 1.78; 95 % CI = 1.18-2.70) and subsidized vs. contributive HIA (HR = 1.44; 95 % CI = 1.13-1.83). The greatest disparity in HR was among women of low SES affiliated to subsidized HIA (vs. contributive HIA and high SES) (HR=2.53; 95 % CI = 1.62-3.97). Despite Colombia's universal healthcare system, important disparities in cervical cancer survival by health insurance affiliation and socioeconomic status remain.
在哥伦比亚等国家,宫颈癌仍然是导致死亡的一个重要原因。我们旨在确定居住地址的社会经济地位(SES)和健康保险关联类型(HIA)是否与哥伦比亚布卡拉曼加的宫颈癌患者的生存相关。通过人群为基础的癌症登记处,确定了在 2008 年至 2016 年间诊断患有浸润性宫颈癌(ICD-0-3 代码 C53.X)的所有居住在布卡拉曼加都会区的患者(n=725),其中 700 名女性的随访数据超过 5 年(研究截止日期:2021 年 12 月 31 日),总体 5 年生存率(95%CI)估计为 56.4%(52.7-60.0%)。为了评估 SES 和 HIA 对宫颈癌生存的影响,我们获得了 5 年总体生存率的 KM 估计值。还进行了多变量 Cox 比例风险建模,包括 SES 和 HIA 之间的交互效应。SES 低与高相比(41.9%比 57.9%,p<0.0001)和 HIA 补贴与缴费相比(45.1%比 63.0%,p<0.0001),5 年总体生存率更低。多变量 Cox 模型显示,SES 低与高相比(HR=1.78;95%CI=1.18-2.70)和 HIA 补贴与缴费相比(HR=1.44;95%CI=1.13-1.83),死亡风险比(HR)增加。在 SES 低且 HIA 补贴的女性中,HR 差异最大(与 HIA 缴费和 SES 高相比)(HR=2.53;95%CI=1.62-3.97)。尽管哥伦比亚拥有全民健康保险制度,但在宫颈癌生存方面,健康保险关联和社会经济地位仍存在显著差异。