Charlotte Fresenius Hochschule, Alte Rabenstraße 32, 20148 Hamburg, Germany; Professorship for Clinical Psychology, Helmut-Schmidt University/ Bundeswehr University Hamburg, Holstenhofweg 85, 22043 Hamburg, Germany.
Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Minderbroedersberg 4-6. P.O. Box 616, Maastricht, MD, 6200, The Netherlands
Neurosci Biobehav Rev. 2023 Aug;151:105221. doi: 10.1016/j.neubiorev.2023.105221. Epub 2023 May 6.
Event-related potentials (ERPs) represent the cortical processing of sensory, motor or cognitive functions invoked by particular events or stimuli. A current theory posits that the catecholaminergic neurotransmitters dopamine (DA) and norepinephrine (NE) modulate a number of endogenous ERPs during various cognitive processes. This manuscript aims to evaluate a leading neurotransmitter hypothesis with a systematic overview and meta-analysis of pharmacologic DA and NE manipulation of specific ERPs in healthy subjects during executive function. Specifically, the frontally-distributed P3a, N2, and N/ERN (or error-related negativity) are supposedly modulated primarily by DA, whereas the parietally-distributed P3b is thought to be modulated by NE. Based on preceding research, we refer to this distinction between frontally-distributed DA-sensitive and parietally-distributed NE-sensitive ERP components as the Extended Neurobiological Polich (ENP) hypothesis. Our systematic review and meta-analysis indicate that this distinction is too simplistic and many factors interact with DA and NE to influence these specific ERPs. These may include genetic factors, the specific cognitive processes engaged, or elements of study design, i.e. session or sequence effects or data-analysis strategies.
事件相关电位（ERPs）代表了特定事件或刺激引发的感觉、运动或认知功能的皮质处理。目前的理论假设，儿茶酚胺递质多巴胺（DA）和去甲肾上腺素（NE）在各种认知过程中调节许多内源性 ERPs。本手稿旨在通过系统综述和荟萃分析，评估一种主要的神经递质假说，即在执行功能期间，健康受试者中药物 DA 和 NE 对特定 ERPs 的操纵。具体来说，额叶分布的 P3a、N2 和 N/ERN（或错误相关负性）据称主要由 DA 调节，而顶叶分布的 P3b 被认为由 NE 调节。基于先前的研究，我们将这种额叶分布的 DA 敏感和顶叶分布的 NE 敏感 ERP 成分之间的区别称为扩展神经生物学多态性（ENP）假说。我们的系统综述和荟萃分析表明，这种区别过于简单化，许多因素与 DA 和 NE 相互作用，影响这些特定的 ERPs。这些因素可能包括遗传因素、参与的特定认知过程或研究设计的要素，即会话或序列效应或数据分析策略。
