Colelli David R, Dela Cruz Gio R, Kendzerska Tetyana, Murray Brian J, Boulos Mark I
Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
UCD School of Medicine, University College Dublin, Dublin, Ireland.
J Sleep Res. 2023 Oct;32(5):e13922. doi: 10.1111/jsr.13922. Epub 2023 May 7.
Morningness-eveningness preference, also known as chronotype, is the tendency for a person to sleep during certain hours of the day and is broadly categorised into morning and evening types. In-laboratory polysomnography (iPSG) is the gold-standard to assess sleep, however, an individual's chronotype is not accounted for in current protocols, which may confound collected sleep data. The objective of our study was to assess if chronotype had an association with sleep physiology. Patients who completed the diagnostic iPSG and the Morningness-Eveningness Questionnaire (MEQ), which categorises patients into morning type, neither or evening type, were assessed. Multivariable linear regression models were used to assess if chronotype was associated with sleep quality, duration, and physiology during iPSG. The study sample included 2612 patients (mean age of 53.6 years, 48% male) recruited during 2010-2015. Morning type, compared with neither type, was significantly associated with an increase in total sleep time and rapid eye movement (REM) sleep, and a decrease in sleep onset latency and the arousal index. Evening type, compared with neither type, was significantly associated with a decrease in total sleep time, sleep efficiency, and REM sleep, and an increase in sleep onset latency and wake after sleep onset. Additionally, iPSG lights out time was significantly different between the different chronotypes. Overall, a morningness chronotype was associated with favourable sleep quality and duration while an eveningness chronotype was associated with reduced sleep quality. Our study quantifies the association of chronotype with iPSG metrics and suggests that laboratory protocols should consider chronotype in their evaluations.
晨型-夜型偏好，也称为昼夜节律类型，是指一个人在一天中特定时间段睡觉的倾向，大致可分为晨型和夜型。实验室多导睡眠图（iPSG）是评估睡眠的金标准，然而，当前的方案并未考虑个体的昼夜节律类型，这可能会混淆所收集的睡眠数据。我们研究的目的是评估昼夜节律类型是否与睡眠生理相关。对完成诊断性iPSG和晨型-夜型问卷（MEQ）的患者进行了评估，该问卷将患者分为晨型、非晨非夜型或夜型。使用多变量线性回归模型来评估昼夜节律类型是否与iPSG期间的睡眠质量、时长和生理状况相关。研究样本包括2010年至2015年招募的2612名患者（平均年龄53.6岁，48%为男性）。与非晨非夜型相比，晨型与总睡眠时间增加、快速眼动（REM）睡眠增加、睡眠起始潜伏期缩短和觉醒指数降低显著相关。与非晨非夜型相比，夜型与总睡眠时间减少、睡眠效率降低、REM睡眠减少、睡眠起始潜伏期延长和睡眠起始后觉醒增加显著相关。此外，不同昼夜节律类型之间的iPSG熄灯时间存在显著差异。总体而言，晨型昼夜节律与良好的睡眠质量和时长相关，而夜型昼夜节律与睡眠质量下降相关。我们的研究量化了昼夜节律类型与iPSG指标之间的关联，并建议实验室方案在评估中应考虑昼夜节律类型。
