Wang Fangyi, Zhou Ying, Hou Xiao, Ni Shifen, Xia Xiaodi, Zhang Tanwei, Zhang Yunyan, Li Xiangyu, Wen Keyi, Wang Yutong, Zhu Wenfen, Fu Yixiao
Department of Psychiatry, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
School of Nursing, Chongqing Medical University, Chongqing, China.
BMC Psychiatry. 2025 May 8;25(1):468. doi: 10.1186/s12888-025-06855-8.
This study explores the relationships among chronotype, sensation seeking, sleep quality and depressive symptoms in adolescents with diagnosed depression, aiming to clarify the mechanisms by which chronotype is associated with depression.
This cross-sectional study assessed 216 adolescents with diagnosed depression using a demographic questionnaire, the Morningness-Eveningness Questionnaire, the Sensation Seeking Scale, the Pittsburgh Sleep Quality Index, and the Beck Depression Inventory. Descriptive and correlational analyses were performed using SPSS 27.0, and structural equation modeling was conducted via AMOS to explore the mediating roles of sensation seeking and sleep quality in the relationship between chronotype and depression.
The study found that 60.6% of adolescents with depression were evening chronotypes. Evening chronotype was associated with higher sensation seeking (r = -0.134, p < 0.05), poorer sleep quality (r = -0.303, p < 0.01), and more severe depressive symptoms (r = -0.376, p < 0.01). Chronotype showed a direct effect on depressive symptoms (effect size = -0.318, 95% CI = -0.602 to -0.049, p < 0.05) and an indirect effect via sleep quality, accounting for 80.5% of the total effect. While sensation seeking alone was not a significant mediator, it contributed to a chain mediation with sleep quality, accounting for 13% of the total effect (combined effect size = -0.053, 95% CI = -0.163 to -0.005, p < 0.01).
Chronotype may play a significant role in adolescent depression, with both direct and indirect effects mediated by sleep quality and sensation seeking. The findings highlight the potential importance of sleep quality as a mediating factor, indicating that interventions targeting sleep improvement could be a promising avenue for further exploration in alleviating depressive symptoms in adolescents.
本研究探讨已确诊患有抑郁症的青少年的昼夜节律类型、寻求刺激、睡眠质量和抑郁症状之间的关系,旨在阐明昼夜节律类型与抑郁症相关联的机制。
这项横断面研究使用人口统计学调查问卷、晨型-夜型问卷、寻求刺激量表、匹兹堡睡眠质量指数和贝克抑郁量表对216名已确诊患有抑郁症的青少年进行了评估。使用SPSS 27.0进行描述性和相关性分析,并通过AMOS进行结构方程建模,以探讨寻求刺激和睡眠质量在昼夜节律类型与抑郁症之间关系中的中介作用。
研究发现,60.6%患有抑郁症的青少年为夜型昼夜节律类型。夜型昼夜节律类型与更高的寻求刺激程度(r = -0.134,p < 0.05)、更差的睡眠质量(r = -0.303,p < 0.01)以及更严重的抑郁症状(r = -0.376,p < 0.01)相关。昼夜节律类型对抑郁症状有直接影响(效应大小 = -0.318,95%置信区间 = -0.602至-0.049,p < 0.05),并通过睡眠质量产生间接影响,占总效应的80.5%。虽然单独的寻求刺激不是一个显著的中介因素,但它促成了与睡眠质量的链式中介作用,占总效应的13%(综合效应大小 = -0.053,95%置信区间 = -0.163至-0.005,p < 0.01)。
昼夜节律类型可能在青少年抑郁症中发挥重要作用,通过睡眠质量和寻求刺激产生直接和间接影响。研究结果凸显了睡眠质量作为中介因素的潜在重要性,表明针对改善睡眠的干预措施可能是进一步探索缓解青少年抑郁症状的一个有前景的途径。