Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Reprod Biomed Online. 2023 Jul;47(1):77-83. doi: 10.1016/j.rbmo.2023.03.011. Epub 2023 Mar 17.
Can preconception adherence to a Mediterranean diet influence the rate of poor response to ovarian stimulation in IVF cycles?
The impact of dietary habits on the success of IVF is controversial. Inconsistencies may be explained by confounders associated with the use of pregnancy as an outcome as well as by a reductionist view of diet that focuses on single components rather than on food patterns. This cross-sectional study analysed adherence to a Mediterranean diet in women with unexpected poor response to ovarian stimulation. Main inclusion criteria were: age 18-39 years, normal weight, preserved ovarian reserve and starting dose of gonadotrophins of 150-225 IU/day. Adherence to the Mediterranean diet was assessed through a Mediterranean diet score (MDS). Unexpected poor ovarian response was defined as the retrieval of ≤3 suitable oocytes.
A total of 296 women were included, of whom 47 (15.9%) showed an unexpected poor response. A clear dose-related association with tertiles of MDS was not observed in the univariate analysis. However, in the multivariate analysis, the risk of unexpected poor response was significantly lower for women in the second tertile of MDS compared with the first tertile (adjusted odds ratio [OR] 0.29, 95% confidence interval [CI] 0.11-0.76) and for women in the second and third tertiles, grouped together, compared with the first tertile (adjusted OR 0.34, 95% CI 0.14-0.82).
Low adherence to a Mediterranean diet could be a risk factor for unexpected poor ovarian response.
孕前地中海饮食的依从性是否会影响 IVF 周期中卵巢刺激反应不良的发生率？
饮食习惯对 IVF 成功率的影响存在争议。不一致的原因可能与将妊娠作为结局相关的混杂因素以及饮食的还原论观点有关，后者侧重于单一成分，而不是食物模式。本横断面研究分析了意外卵巢刺激反应不良的女性对地中海饮食的依从性。主要纳入标准为：年龄 18-39 岁、体重正常、卵巢储备正常、起始促性腺激素剂量为 150-225IU/天。通过地中海饮食评分（MDS）评估地中海饮食的依从性。意外卵巢反应不良定义为获得的合适卵子数≤3 个。
共纳入 296 名女性，其中 47 名（15.9%）表现出意外卵巢反应不良。在单因素分析中，未观察到 MDS 三分位与卵巢反应不良之间存在明显的剂量相关性。然而，在多因素分析中，与 MDS 第一三分位相比，第二三分位的女性发生意外卵巢反应不良的风险显著降低（调整后的优势比[OR]0.29，95%置信区间[CI]0.11-0.76），并且第二和第三三分位的女性合并在一起，与第一三分位相比，发生意外卵巢反应不良的风险也显著降低（调整后的 OR 0.34，95%CI 0.14-0.82）。
低水平的地中海饮食依从性可能是意外卵巢反应不良的一个危险因素。
