Department of Dermatology and Venereology, İstinye University Faculty of Medicine, Istanbul, Turkey.
Department of Pathology, Health Science University Umraniye Training and Research Hospital, Istanbul, Turkey.
Int J Surg Pathol. 2024 Apr;32(2):252-262. doi: 10.1177/10668969231173381. Epub 2023 May 7.
Dermatopathic lymphadenopathy is a well-defined histopathological entity with an underestimated prevalence in the general population. The present study was conducted to analyze the characteristics of histologically diagnosed cases of dermatopathic lymphadenopathy at our unit. We also aimed to investigate any association between the clinical features of the patients and the histological findings. A total of 39 lymph node samples from 39 patients diagnosed with dermatopathic lymphadenopathy were included in this prospective cohort study. Thirty-four (87%) patients had a dermatological disorder. The presence of paracortical eosinophils were significantly higher in patients with dermatological disorders ( = .001), while the presence of dilated sinuses was significantly more common in patients without a dermatological disorder ( = .035). The presence of dilated sinuses and medullary histiocytes were significantly more common in patients with lower body surface area involvement of the disease compared to the ones with a higher body surface area ( = .003, = .034; respectively). Most of the patients included in the study had one of a broad spectrum of undiagnosed dermatological disorders. The clinical significance of the relation between histological and clinical findings in dermatopathic lymphadenopathy remains to be explained. Dermatopathic lymphadenopathy should always be considered in differential diagnoses of patients with persistent lymph node enlargement even when absolute dermatological disorders are not present. Since various skin disorders may be the cause of lymphadenopathy, performing a full-body examination before lymph node excision might prevent unneccessary procedures.
皮肤病相关性淋巴结病是一种明确的组织病理学实体，其在普通人群中的患病率被低估。本研究旨在分析我们单位经组织学诊断的皮肤病相关性淋巴结病病例的特征，并探讨患者的临床特征与组织学发现之间是否存在任何关联。这项前瞻性队列研究共纳入了 39 例经组织学诊断为皮肤病相关性淋巴结病的患者的 39 个淋巴结样本。34 例（87%）患者存在皮肤病。存在皮质旁嗜酸性粒细胞的患者中，皮肤病的存在明显更高（ = .001），而无皮肤病的患者中，扩张的窦道更为常见（ = .035）。与病变累及体表面积较大的患者相比，病变累及体表面积较小的患者中扩张的窦道和髓质组织细胞更为常见（ = .003， = .034；分别）。研究纳入的大多数患者都有一种广泛的未确诊的皮肤病。皮肤病相关性淋巴结病中组织学和临床发现之间的关系的临床意义仍有待解释。即使不存在绝对的皮肤病，对于持续性淋巴结肿大的患者，也应始终考虑将皮肤病相关性淋巴结病作为鉴别诊断。由于各种皮肤疾病可能是淋巴结病的原因，在进行淋巴结切除术前进行全身检查可能会避免不必要的操作。
