hTDP - 43在神经元中的过表达会损害不同的神经元控制行为并降低繁殖力。
Neuronal overexpression of hTDP-43 in impairs different neuronally controlled behaviors and decreases fecundity.
作者信息
Koopman Mandy, Güngördü Lale, Seinstra Renée I, Nollen Ellen A A
机构信息
European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, Laboratory of Molecular Neurobiology of Ageing, The Netherlands.
European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, The Netherlands.
出版信息
MicroPubl Biol. 2023 Apr 19;2023. doi: 10.17912/micropub.biology.000769. eCollection 2023.
Cytoplasmic inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a key hallmark of TDP-43 proteinopathies like amyotrophic lateral sclerosis (ALS). is considered a useful model for studying the molecular mechanisms underlying TDP-43 toxicity . Here, we assessed different neuronal systems through established behavioral assays and extended the phenotypic characterisation of a model expressing wildtype human ( ) pan-neuronally. Our data show that neuronal expression of hTDP-43 in disrupts chemotaxis and decreases fecundity. The basal slowing response, on the other hand, appears to be preserved in the presence of hTDP-43.
由反式激活反应DNA结合蛋白43（TDP - 43）组成的细胞质内含物是肌萎缩侧索硬化症（ALS）等TDP - 43蛋白病的关键标志。被认为是研究TDP - 43毒性潜在分子机制的有用模型。在这里，我们通过既定的行为分析评估了不同的神经元系统，并扩展了在全神经元中表达野生型人类TDP - 43（hTDP - 43）的模型的表型特征。我们的数据表明，秀丽隐杆线虫中hTDP - 43的神经元表达会破坏趋化性并降低繁殖力。另一方面，在存在hTDP - 43的情况下，基础缓慢反应似乎得以保留。
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