Department of Pharmaceutics and Pharmaceutical Technology, L.M. College of Pharmacy, Ahmedabad, Gujarat 380009, India.
Department of Pharmacology, L. M. College of Pharmacy, Niangua, Ahmedabad, Gujarat 380009, India.
Nanotheranostics. 2023 May 1;7(4):368-379. doi: 10.7150/ntno.82263. eCollection 2023.
Cancer diagnosis and management have been a slow-evolving area in medical science. Conventional therapies have by far proved to have various limitations. Also, the concept of immunotherapy which was thought to revolutionize the management of cancer has presented its range of drawbacks. To overcome these limitations nanoparticulate-derived diagnostic and therapeutic strategies are emerging. These nanomaterials are to be explored as they serve as a prospect for cancer theranostics. Nanoparticles have a significant yet unclear role in screening as well as therapy of cancer. However, nanogels and Photodynamic therapy is one such approach to be developed in cancer theranostics. Photoactive cancer theranostics is a vivid area that might prove to help manage cancer. Also, the utilization of the quantum dots as a diagnostic tool and to selectively kill cancer cells, especially in CNS tumors. Additionally, the redox-sensitive micelles targeting the tumor microenvironment of the cancer are also an important theranostic tool. This review focuses on exploring various agents that are currently being studied or can further be studied as cancer theranostics.
癌症的诊断和治疗一直是医学科学中一个缓慢发展的领域。到目前为止，传统疗法已经被证明存在各种局限性。此外，免疫疗法的概念被认为可以彻底改变癌症的治疗，但它也存在一系列的缺点。为了克服这些局限性，基于纳米颗粒的诊断和治疗策略正在兴起。这些纳米材料将被探索，因为它们为癌症的诊断和治疗提供了前景。纳米颗粒在癌症的筛查和治疗中具有重要但尚未明确的作用。然而，纳米凝胶和光动力疗法是癌症诊断和治疗中正在开发的一种方法。光活性癌症诊断和治疗是一个充满活力的领域，可能有助于癌症的治疗。此外，利用量子点作为诊断工具并选择性地杀死癌细胞，特别是在中枢神经系统肿瘤中。此外，针对癌症肿瘤微环境的氧化还原敏感胶束也是一种重要的诊断和治疗工具。本综述重点探讨了目前正在研究或可以进一步作为癌症诊断和治疗研究的各种药物。
