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基于纳米诊断的头颈部癌症管理。

Nanotheranostics-based Management of Head and Neck Cancer.

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, L.M. College of Pharmacy, Ahmedabad, India.

Pharmacy Section, L.M. College of Pharmacy, Ahmedabad, India.

出版信息

Nanotheranostics. 2023 Feb 5;7(2):202-209. doi: 10.7150/ntno.81724. eCollection 2023.

DOI:10.7150/ntno.81724
PMID:36793352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9925351/
Abstract

Head and neck cancer is affecting a large sort of population. Many treatments are available on a regular base, but they have their limitations. Diagnosis in the early stage is essential to cope with the disease which is a limitation in the majority of present diagnostic tools. Many of them are invasive methods that lead to patient discomfort. Interventional nanothernostics is an emerging field in the management of Head and Neck cancer. It facilitates both diagnostic and therapeutic approaches. It also helps with the overall management of the disease. This method allows the early and accurate detection of the disease which improvises the chances of recovery. Additionally, it makes sure that the medicine is delivered specifically to increase clinical outcomes and reduce side effects. The use of radiation in addition to the medicine supplied can produce a synergistic effect. It contains several nanoparticles, including silicon and gold nanoparticles. This review paper focuses on the shortcomings of existing therapeutic techniques and how nanotheranostics fills the void.

摘要

头颈部癌症正在影响大量人群。许多常规治疗方法都可应用,但它们都有其局限性。早期诊断对于应对这种疾病至关重要,而目前大多数诊断工具都存在这一局限性。其中许多方法都是侵入性的,会导致患者不适。介入性纳米诊断治疗是头颈部癌症治疗中的一个新兴领域。它既可以促进诊断,也可以促进治疗。它还有助于疾病的整体管理。这种方法可以早期、准确地发现疾病,从而提高康复的机会。此外,它还可以确保药物的专门递送,以提高临床疗效,减少副作用。联合使用药物和放射治疗可以产生协同效应。该治疗方法包含几种纳米颗粒,包括硅纳米颗粒和金纳米颗粒。本文综述了现有治疗技术的缺点,以及纳米诊断治疗如何填补这一空白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/8d55bd541a14/ntnov07p0202g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/7990c8da8349/ntnov07p0202g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/0e6077746cc0/ntnov07p0202g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/8d55bd541a14/ntnov07p0202g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/7990c8da8349/ntnov07p0202g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/0e6077746cc0/ntnov07p0202g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9a/9925351/8d55bd541a14/ntnov07p0202g003.jpg

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本文引用的文献

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Advances in nanomaterials for the diagnosis and treatment of head and neck cancers: A review.用于头颈癌诊断与治疗的纳米材料研究进展:综述
Bioact Mater. 2022 Sep 2;25:430-444. doi: 10.1016/j.bioactmat.2022.08.010. eCollection 2023 Jul.
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Interventional nanotheranostics in hepatocellular carcinoma.肝细胞癌的介入纳米治疗学。
Nanotheranostics. 2023 Jan 9;7(2):128-141. doi: 10.7150/ntno.80120. eCollection 2023.
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Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors.头颈部癌症的流行病学回顾:定义、趋势和危险因素。
Cancers (Basel). 2023 Nov 24;15(23):5572. doi: 10.3390/cancers15235572.
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Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors.用于实体瘤诊疗的共轭纳米颗粒:解析已知与未知因素的相互作用
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Nanotheranostics: The Fabrication of Theranostics with Nanoparticles and their Application to Treat the Neurological Disorders.纳米诊疗学:基于纳米颗粒的诊疗制剂的制备及其在治疗神经疾病中的应用
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Endogenous stimuli-responsive nanoparticles for cancer therapy: From bench to bedside.内源性刺激响应纳米颗粒用于癌症治疗:从实验室到临床。
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