Rao K S, Fernando J C, Ho I K, Mehendale H M
Res Commun Chem Pathol Pharmacol. 1986 May;52(2):217-24.
Rats were treated with amiodarone (20 mg/kg/day) up to 6 weeks and the neurotoxicity was assessed by determining changes in motor coordination, pain-threshold and rectal temperature every week during treatment. Body weight gain was decreased during amiodarone treatment and it was significant at and after 5 weeks. Food intake and water consumption were significantly reduced during treatment. After the first week of treatment with amiodarone, rats showed decreased ability to balance on horizontal rods. In the hot plate test (paw-lick), the amiodarone treated rats showed increased pain-thresholds throughout the treatment. Hypothermia was significant only at 6 weeks. These results show that amiodarone causes toxicity in rats and this model might be useful for further studies. Decreased motor-coordination, and increased pain-responding times may indicate development of peripheral neuropathy in addition to muscle weakness.
大鼠接受胺碘酮（20毫克/千克/天）治疗长达6周，并在治疗期间每周通过测定运动协调性、痛阈和直肠温度的变化来评估神经毒性。胺碘酮治疗期间体重增加减少，在第5周及之后显著。治疗期间食物摄入量和饮水量显著减少。用胺碘酮治疗第一周后，大鼠在水平杆上保持平衡的能力下降。在热板试验（舔爪）中，接受胺碘酮治疗的大鼠在整个治疗过程中痛阈升高。体温过低仅在第6周时显著。这些结果表明胺碘酮在大鼠中引起毒性，该模型可能对进一步研究有用。运动协调性下降和疼痛反应时间增加可能表明除肌肉无力外还发生了周围神经病变。
