Jiang Xiaohan, Jin Ziyao, Yang Yuzhong, Zheng Xiang, Chen Shaohua, Wang Shuaijie, Zhang Xuemei, Qu Nanfang
Department of Pathology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China.
Front Oncol. 2023 Apr 21;13:1162300. doi: 10.3389/fonc.2023.1162300. eCollection 2023.
N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism, including translocation, mRNA stability or decay, pre-mRNA splicing, and lncRNA processing. Numerous studies have shown that m6A modification is involved in the development of various cancers. This review aims to summarize the significant role of m6A modification in the proliferation and tumorigenesis of CRC, as well as the potential of modulating m6A modification for tumor treatment. These findings may offer new therapeutic strategies for clinical implementation of m6A modification in CRC in the near future.
N6-甲基腺苷（m6A）是真核细胞中最普遍的RNA修饰。RNA的动态可逆m6A修饰通过调节RNA代谢，包括转运、mRNA稳定性或降解、前体mRNA剪接和长链非编码RNA加工，在肿瘤的发生和发展中起关键作用。大量研究表明，m6A修饰参与了各种癌症的发展。本综述旨在总结m6A修饰在结直肠癌增殖和肿瘤发生中的重要作用，以及调节m6A修饰用于肿瘤治疗的潜力。这些发现可能在不久的将来为m6A修饰在结直肠癌临床应用中提供新的治疗策略。
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