砷与糖尿病：免疫系统的潜在作用。
Arsenic and Diabetes Mellitus: A Putative Role for the Immune System.
作者信息
Liu Jingli, Hermon Tonia, Gao Xiaohua, Dixon Darlene, Xiao Hang
机构信息
Molecular Pathogenesis Group, Mechanistic Toxicology Branch, Division of the National Toxicology Program (DNTP), National Institute of Environmental Health Sciences (NIEHS), NIH, DHHS, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Key Lab of Modern Toxicology (NJMU), Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu, China.
出版信息
All Life. 2023;16(1). doi: 10.1080/26895293.2023.2167869. Epub 2023 Feb 1.
Diabetes mellitus (DM) is an enormous public health issue worldwide. Recent data suggest that chronic arsenic exposure is linked to the risk of developing type 1 and type 2 DM, albeit the underlying mechanisms are unclear. This review discusses the role of the immune system as a link to possibly explain some of the mechanisms of developing T1DM or T2DM associated with arsenic exposure in humans, animal models, and studies. The rationale for the hypothesis includes: (1) Arsenic is a well-recognized modulator of the immune system; (2) arsenic exposures are associated with increased risk of DM; and (3) dysregulation of the immune system is one of the hallmarks in the pathogenesis of both T1DM and T2DM. A better understanding of DM in association with immune dysregulation and arsenic exposures may help to understand how environmental exposures modulate the immune system and how these effects may impact the manifestation of disease.
糖尿病（DM）是一个全球性的重大公共卫生问题。近期数据表明，长期接触砷与患1型和2型糖尿病的风险有关，尽管其潜在机制尚不清楚。本综述讨论了免疫系统作为一种联系的作用，以可能解释在人类、动物模型和研究中与砷暴露相关的1型糖尿病或2型糖尿病发病的一些机制。该假设的理论依据包括：（1）砷是一种公认的免疫系统调节剂；（2）砷暴露与糖尿病风险增加有关；（3）免疫系统失调是1型糖尿病和2型糖尿病发病机制的特征之一。更好地理解与免疫失调和砷暴露相关的糖尿病，可能有助于了解环境暴露如何调节免疫系统，以及这些影响如何可能影响疾病的表现。
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