酒精性肝病中的膳食胆固醇。
Dietary cholesterol in alcohol-associated liver disease.
作者信息
Jia Lin
机构信息
Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.
出版信息
Immunometabolism (Cobham). 2023 May 3;5(2):e00026. doi: 10.1097/IN9.0000000000000026. eCollection 2023 Apr.
There is an increasing prevalence of alcohol-associated liver disease (ALD) worldwide. In addition to excessive alcohol consumption, other nutritional factors have been shown to affect the initiation and progression of ALD. The emerging role of cholesterol in exacerbating ALD has been reported recently and the underlying mechanisms are discussed. In addition, the interplay between dietary cholesterol and alcohol on cholesterol metabolism is reviewed. Furthermore, we highlight the therapeutic potential of cholesterol-lowering drugs in managing the onset and severity of ALD. Finally, we suggest the future mechanistic investigation of the effect of cholesterol on insulin resistance and intestinal inflammation in the exacerbation of alcohol-induced cellular and systemic dysfunction.
全球范围内，酒精性肝病（ALD）的患病率呈上升趋势。除过量饮酒外，其他营养因素也已被证明会影响ALD的发生和发展。最近有报道称胆固醇在加重ALD方面发挥着新作用，并对其潜在机制进行了讨论。此外，还综述了膳食胆固醇与酒精在胆固醇代谢方面的相互作用。此外，我们强调了降低胆固醇药物在控制ALD的发生和严重程度方面的治疗潜力。最后，我们建议未来对胆固醇在酒精诱导的细胞和全身功能障碍加重过程中对胰岛素抵抗和肠道炎症影响的机制进行研究。
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