Aby Elizabeth S, Vogel Alexander S, Winters Adam C
Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota.
Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Clin Ther. 2023 Dec;45(12):1164-1170. doi: 10.1016/j.clinthera.2023.08.019. Epub 2023 Sep 26.
This review will provide an overview of alcohol use and alcohol associated liver disease (ALD) prior to the coronavirus disease 2019 (COVID-19) pandemic and the impact of the pandemic on alcohol use and ALD. Furthermore, this review will explore strategies to mitigate the growing disease burden of AUD and ALD.
A search using PubMed was performed for articles on topics related to alcohol use, ALD, and COVID-19. The literature was reviewed and pertinent sources were used for this narrative review.
In the United States (US), excessive alcohol use is the third leading cause of preventable death. Prior to the COVID-19 pandemic, the increasing prevalence of alcohol use disorder (AUD) and ALD in the US had already constituted a public health crisis given the association between alcohol misuse, AUD, and ALD with significant medical, economic, and societal burdens. The COVID-19 pandemic led to increased alcohol consumption and downstream consequences, including increased prevalence of AUD, ALD, ALD-related hospitalization and death, and liver transplantation for ALD.
There is a critical need for additional, multi-pronged interventions to mitigate the mortality and morbidity linked to ALD.
本综述将概述2019年冠状病毒病（COVID-19）大流行之前的酒精使用情况及酒精相关肝病（ALD），以及该大流行对酒精使用和ALD的影响。此外，本综述将探讨减轻酒精使用障碍（AUD）和ALD日益加重的疾病负担的策略。
使用PubMed搜索有关酒精使用、ALD和COVID-19相关主题的文章。对文献进行了综述，并将相关资料用于本叙述性综述。
在美国，过度饮酒是可预防死亡的第三大主要原因。在COVID-19大流行之前，鉴于酒精滥用、AUD和ALD与重大医疗、经济和社会负担之间的关联，美国酒精使用障碍（AUD）和ALD患病率的上升已经构成了一场公共卫生危机。COVID-19大流行导致酒精消费增加及其下游后果，包括AUD、ALD患病率上升，ALD相关住院和死亡增加，以及因ALD进行肝移植。
迫切需要采取额外的多方面干预措施，以减轻与ALD相关的死亡率和发病率。
