Jain Shivani, Parrotte Samantha, Anyanwu Chikamuche, Fairchild Alexandra H
Department of Interventional Radiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.
Semin Intervent Radiol. 2023 May 4;40(1):3-8. doi: 10.1055/s-0043-1764281. eCollection 2023 Feb.
Sarcopenia is a progressive muscle wasting syndrome involving loss in skeletal muscle mass, strength, and function. It is closely associated with cirrhosis and its complications with up to more than half of cirrhotic patients demonstrating imaging findings of sarcopenia. The pathogenesis of this syndrome remains complex, including multiple factors involved in skeletal muscle homeostasis, systemic inflammation, and energy dysregulation. Many modalities exist in assessing and measuring sarcopenia. The use of cross-sectional imaging, such as computed tomography and magnetic resonance imaging, with accurate and clinically proven assessment software should be considered the gold standard. Sarcopenia has become the focus of ongoing extensive research with initial findings highlighting increased mortality and complication rates in patient with cirrhosis and hepatocellular carcinoma. Additional studies have demonstrated reversal and improved survival in sarcopenic patients who have undergone transjugular intrahepatic portosystemic shunt placement. Thus, accounting for sarcopenia can help risk stratify patients prior to interventional procedures to allow for better outcomes and improved survival.
肌肉减少症是一种进行性肌肉消耗综合征，涉及骨骼肌质量、力量和功能的丧失。它与肝硬化及其并发症密切相关，超过一半的肝硬化患者表现出肌肉减少症的影像学表现。该综合征的发病机制仍然复杂，包括参与骨骼肌稳态、全身炎症和能量失调的多种因素。评估和测量肌肉减少症有多种方法。使用横断面成像，如计算机断层扫描和磁共振成像，并结合准确且经临床验证的评估软件，应被视为金标准。肌肉减少症已成为正在进行的广泛研究的焦点，初步研究结果强调了肝硬化和肝细胞癌患者的死亡率和并发症发生率增加。更多研究表明，接受经颈静脉肝内门体分流术的肌肉减少症患者病情得到逆转，生存率提高。因此，在进行介入手术前考虑肌肉减少症有助于对患者进行风险分层，以获得更好的结果和提高生存率。
