Kim Kyoung Min, Ahn Ae Ri, Hong Yong Tae, Chung Myoung Ja
Department of Pathology, Jeonbuk National University Medical School, Jeonbuk National University, Jeonju, Jeollabuk 54896, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University, Jeonbuk National University, Jeonju, Jeollabuk 54896, Republic of Korea.
Oncol Lett. 2023 Apr 18;25(6):233. doi: 10.3892/ol.2023.13819. eCollection 2023 Jun.
Primary small cell thyroid carcinomas are extremely rare and there is still debate about their classification as a distinct disease entity. The present case report reports a small cell carcinoma (SCC) combined with poorly differentiated thyroid carcinoma (PDTC) in a 34 year old man. The tumor consisted of ~80% PDTC and ~20% SCC. The PDTC component was positive for cytokeratin and thyroid transcription factor-1 (TTF-1), and negative for calcitonin, chromogranin and synaptophysin. The SCC component was positive for synaptophysin and CD56, and negative for calcitonin, chromogranin and TTF-1. Seven months after thyroid surgery, two new lung nodules were detected. Histologically and immunohistochemically, the lung tumors were similar to the SCC component of the thyroid carcinoma. The mutational status of cancer-related genes was assessed using targeted next-generation sequencing in both the thyroid and lung, which identified similar genetic alterations. The histogenesis of SCC was evaluated through NGS analysis of the two cancer components.
原发性小细胞甲状腺癌极为罕见，关于将其归类为一种独特的疾病实体仍存在争议。本病例报告报道了一名34岁男性患有小细胞癌（SCC）合并低分化甲状腺癌（PDTC）。肿瘤由约80%的PDTC和约20%的SCC组成。PDTC成分细胞角蛋白和甲状腺转录因子-1（TTF-1）呈阳性，降钙素、嗜铬粒蛋白和突触素呈阴性。SCC成分突触素和CD56呈阳性，降钙素、嗜铬粒蛋白和TTF-1呈阴性。甲状腺手术后七个月，发现了两个新的肺结节。从组织学和免疫组织化学来看，肺肿瘤与甲状腺癌的SCC成分相似。在甲状腺和肺中均使用靶向二代测序评估癌症相关基因的突变状态，发现了相似的基因改变。通过对两种癌症成分的NGS分析评估SCC的组织发生。
