Soares Correia Rui, França Margarida
Department of Internal Medicine, Centro Hospitalar Tondela-Viseu - Epe, Viseu, PRT.
Department of Internal Medicine, Centro Hospitalar do Porto, Porto, PRT.
Cureus. 2023 Apr 3;15(4):e37063. doi: 10.7759/cureus.37063. eCollection 2023 Apr.
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are two chronic viral infections that share the same mode of transmission, making HIV/HCV coinfection frequent. Highly active antiretroviral therapy (HAART) was a turning point in HIV treatment and has been shown to successfully restore immune function and reduce the frequency of opportunistic infections. Despite a virological response to HAART, a proportion of patients fail to achieve substantial immune recovery, as measured by peripheral CD4 cell counts. Herein, we present the case of a patient with HIV/HCV coinfection who did not achieve successful immune function restoration despite HIV suppression and HCV treatment. Our goal is to promote discussion. Despite considerable advances in the understanding of the impact of HCV on HIV disease progression, there are many individual variables that influence a patient's immune function. In addition, we consider hypogammaglobulinemia as a possible contributor. Further understanding and improvement of immune reconstitution in patients infected with HIV remain an important field of scientific research.
人类免疫缺陷病毒（HIV）和丙型肝炎病毒（HCV）感染是两种具有相同传播方式的慢性病毒感染，这使得HIV/HCV合并感染很常见。高效抗逆转录病毒疗法（HAART）是HIV治疗的一个转折点，已被证明能成功恢复免疫功能并降低机会性感染的发生率。尽管对HAART有病毒学反应，但仍有一部分患者未能实现外周血CD4细胞计数所衡量的实质性免疫恢复。在此，我们报告一例HIV/HCV合并感染患者的病例，该患者尽管HIV得到抑制且接受了HCV治疗，但仍未成功恢复免疫功能。我们的目标是促进讨论。尽管在理解HCV对HIV疾病进展的影响方面取得了相当大的进展，但仍有许多个体变量会影响患者的免疫功能。此外，我们认为低丙种球蛋白血症可能是一个促成因素。进一步了解和改善HIV感染患者的免疫重建仍然是一个重要的科研领域。
