Ramanarasimhaiah Raghunath, Colef Robert, Kiran Nfn, Mody Kokila
Pathology and Laboratory Medicine, Northwell Health, Staten Island, USA.
Pathology and Laboratory Medicine, Northwell Health, New York, USA.
Cureus. 2023 Apr 4;15(4):e37137. doi: 10.7759/cureus.37137. eCollection 2023 Apr.
Littoral cell angioma (LCA) is a rare, primary vascular tumor of the spleen that originates from the cells lining the venous sinuses of the spleen. Around 150 cases have been reported worldwide, with most reported cases of LCA being non-malignant but with unspecified malignant potential. As of 2022, three cases of malignant LCA have been reported. A 75-year-old male with a history of monoclonal gammopathy of uncertain significance presented with left upper outer quadrant abdominal pain. Ultrasound (US) scan showed a 10.5 cm round, circumscribed mass lesion, with hyperechoic foci, occupying the posterolateral aspect of the spleen. US-guided core needle biopsy of the mass revealed a diagnosis of "atypical cells present, suggestive of vascular neoplasm of the spleen," which was based on histologic and immunohistochemistry characteristics. Due to the size of the lesion, a malignant neoplasm was suspected, and a splenectomy was performed. Histological and immunohistochemical features of the splenic lesion returned a final diagnosis of benign LCA.
脾窦岸细胞血管瘤（LCA）是一种罕见的脾脏原发性血管肿瘤，起源于脾静脉窦的内皮细胞。全球已报告约150例病例，大多数报告的LCA病例为非恶性，但恶性潜能未明确。截至2022年，已报告3例恶性LCA。一名75岁男性，有意义未明的单克隆丙种球蛋白病病史，出现左上腹外侧象限腹痛。超声（US）扫描显示一个10.5 cm圆形、边界清晰的肿块病变，伴有高回声灶，占据脾脏后外侧。对该肿块进行US引导下的粗针活检，根据组织学和免疫组化特征诊断为“存在非典型细胞，提示脾脏血管肿瘤”。由于病变大小，怀疑为恶性肿瘤，遂行脾切除术。脾脏病变的组织学和免疫组化特征最终诊断为良性LCA。
