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给予源自prosaposin的神经营养因子可促进神经管缺陷的再生并恢复神经功能。

Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions.

作者信息

Khan Sakirul, Takeuchi Akihide, Nabeka Hiroaki, Khan Farzana, Shimokawa Tetsuya, Takanezawa Sota, Saitou Takashi, Imamura Takeshi, Tachibana Tetsuya, Nishizono Akira, Hamada Fumihiko, Matsuda Seiji

机构信息

Department of Developmental Biology and Functional Genomics, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.

Department of Microbiology, Faculty of Medicine, Oita University, Yufu, Oita 879-5593, Japan.

出版信息

iScience. 2023 Feb 28;26(4):106277. doi: 10.1016/j.isci.2023.106277. eCollection 2023 Apr 21.

DOI:10.1016/j.isci.2023.106277
PMID:37153447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10156616/
Abstract

Neural tube defects (NTDs) cause fetal and pediatric deaths or lifelong neurological disabilities. No effective treatment is currently available for NTDs. We attempted to elucidate the pathogenesis of NTDs and propose a therapeutic strategy. Intra-amniotic treatment with prosaposin-derived 18-mer peptide (PS18) protected the spinal cord from secondary damage and rescued neurological function in an established chicken model of spina bifida aperta (SBA), the severe type of NTDs. PS18 promoted the formation of a neuroectodermal covering over the defective neural tube within 24-h after treatment, enhanced the regeneration/restoration process, and decreased apoptotic activity in the developing spinal cord. PS18 reduced the SBA wound and almost completely formed the spinal cord. SBA chicks that received PS18 exhibited relatively normal walking and sensorimotor responses, and reduced pain-associated behavior in postnatal life. In conclusion, PS18 is a promising therapeutic agent for NTDs and may be useful for treating other types of spinal cord injuries.

摘要

神经管缺陷（NTDs）会导致胎儿和儿童死亡或终身神经残疾。目前尚无针对NTDs的有效治疗方法。我们试图阐明NTDs的发病机制并提出一种治疗策略。在已建立的开放性脊柱裂（SBA，一种严重类型的NTDs）鸡模型中，羊膜腔内注射prosaposin衍生的18肽（PS18）可保护脊髓免受继发性损伤并挽救神经功能。PS18在治疗后24小时内促进了缺陷神经管上神经外胚层覆盖物的形成，增强了再生/修复过程，并降低了发育中脊髓的凋亡活性。PS18缩小了SBA伤口并几乎完全形成了脊髓。接受PS18治疗的SBA雏鸡在出生后表现出相对正常的行走和感觉运动反应，并减少了与疼痛相关的行为。总之，PS18是一种有前途的NTDs治疗药物，可能对治疗其他类型的脊髓损伤有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/4537a2498a85/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/0be97aa2c3be/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/69ac9a150f09/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/a2864e97b63c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/bb9d1ebbd95b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/d3235ef34c74/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/7a5dffac9551/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/bc28eecd67af/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/d8814d38ce03/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/a7a7a2251d81/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/4537a2498a85/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/0be97aa2c3be/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/69ac9a150f09/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/a2864e97b63c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/bb9d1ebbd95b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/d3235ef34c74/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/7a5dffac9551/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/bc28eecd67af/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/d8814d38ce03/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/a7a7a2251d81/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a13/10156616/4537a2498a85/gr9.jpg

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