Wu Ting, Zhou Kaiyu, Hua Yimin, Zhang Wen, Li Yifei
Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu, China.
Department of Ultrasonic Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Front Pharmacol. 2023 Apr 20;14:1164487. doi: 10.3389/fphar.2023.1164487. eCollection 2023.
The "developmental origins of health and disease" (DOHaD) hypothesis posits that early-life environmental exposures have a lasting impact on individual's health and permanently shape growth, structure, and metabolism. This reprogramming, which results from fetal stress, is believed to contribute to the development of adulthood cardiovascular diseases such as hypertension, coronary artery disease, heart failure, and increased susceptibility to ischemic injuries. Recent studies have shown that prenatal exposure to drugs, such as glucocorticoids, antibiotics, antidepressants, antiepileptics, and other toxins, increases the risk of adult-onset cardiovascular diseases. In addition, observational and animal experimental studies have demonstrated the association between prenatal drug exposure and the programming of cardiovascular disease in the offspring. The molecular mechanisms underlying these effects are still being explored but are thought to involve metabolism dysregulation. This review summarizes the current evidence on the relationship between prenatal drug exposure and the risk of adult cardiovascular disorders. Additionally, we present the latest insights into the molecular mechanisms that lead to programmed cardiovascular phenotypes after prenatal drug exposure.
“健康与疾病的发育起源”（DOHaD）假说认为，生命早期的环境暴露会对个体健康产生持久影响，并永久性地塑造生长、结构和新陈代谢。这种由胎儿应激导致的重编程被认为会促使成年期心血管疾病的发展，如高血压、冠状动脉疾病、心力衰竭以及对缺血性损伤易感性增加。最近的研究表明，产前接触药物，如糖皮质激素、抗生素、抗抑郁药、抗癫痫药和其他毒素，会增加成年后患心血管疾病的风险。此外，观察性研究和动物实验研究已经证实了产前药物暴露与后代心血管疾病编程之间的关联。这些影响背后的分子机制仍在探索中，但被认为涉及代谢失调。本综述总结了目前关于产前药物暴露与成年心血管疾病风险之间关系的证据。此外，我们还介绍了产前药物暴露后导致心血管表型编程的分子机制的最新见解。
