Department of Pediatric Metabolism Faculty of Medicine, Ankara University, Ankara, Turkey.
Department of Clinical Biochemistry, Inonu University Faculty of Medicine, Malatya, Turkey.
Fetal Pediatr Pathol. 2023 Aug;42(4):599-613. doi: 10.1080/15513815.2023.2183026. Epub 2023 May 8.
The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D levels of obese children were lower than those of pre-obese and normal weight (p < 0.05). In the normal weight group, total thiol and native thiol were lower in the pubertal period than in adolescence; were higher in those with sufficient Vitamin-D level than those with insufficient and deficient Vitamin-D (p < 0.05). Vitamin-D level was lower in pre-obese girls than boys (p < 0.05). Those with high triglycerides had high disulfide/total thiol, disulfide, and disulfide/native thiol and low native thiol/total thiol (p < 0.05). Thiol-disulfide homeostasis is negatively affected by low vitamin D levels, pubertal period and high triglyceride levels.
本研究旨在探讨肥胖、维生素 D 缺乏与蛋白质氧化之间的关系。比较了肥胖、超重和正常体重健康儿童的硫醇-二硫键平衡、维生素 D、缺血修饰白蛋白、胰岛素和脂质水平。共纳入 136 名儿童（69 名男孩和 67 名女孩）。肥胖儿童的维生素 D 水平低于超重和正常体重儿童（p<0.05）。在正常体重组中，青春期的总巯基和天然巯基低于青春期；维生素 D 水平充足者高于不足和缺乏者（p<0.05）。超重女孩的维生素 D 水平低于男孩（p<0.05）。甘油三酯水平高者二硫键/总巯基、二硫键和二硫键/天然巯基升高，天然巯基/总巯基降低（p<0.05）。低维生素 D 水平、青春期和高甘油三酯水平会对硫醇-二硫键平衡产生负面影响。
