肺部内用分枝杆菌噬菌体 LysB 可快速降低脓肿分枝杆菌负荷。
Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden.
机构信息
Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA.
出版信息
Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0016223. doi: 10.1128/aac.00162-23. Epub 2023 May 8.
Abstract
Intrinsic and acquired antibiotic resistance in Mycobacterium abscessus presents challenges in infection control, and new therapeutic strategies are needed. Bacteriophage therapy shows promise, but variabilities in M. abscessus phage susceptibility limits its broader utility. We show here that a mycobacteriophage-encoded lysin B (LysB) efficiently and rapidly kills both smooth- and rough-colony morphotype M. abscessus strains and reduces the pulmonary bacterial load in mice. LysB aerosolization presents a plausible treatment for pulmonary M. abscessus infections.
摘要
分枝杆菌属的固有和获得性抗生素耐药性给感染控制带来了挑战，需要新的治疗策略。噬菌体治疗显示出了前景，但分枝杆菌噬菌体的敏感性存在差异，限制了其更广泛的应用。我们在这里表明，一种分枝杆菌噬菌体编码的溶菌酶 B（LysB）可以有效地快速杀死光滑菌落和粗糙菌落形态的脓肿分枝杆菌菌株，并降低小鼠肺部的细菌负荷。LysB 的雾化吸入可能是治疗肺部脓肿分枝杆菌感染的一种合理方法。
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