The Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan.
Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Antioxid Redox Signal. 2023 Oct;39(10-12):728-743. doi: 10.1089/ars.2022.0191. Epub 2023 Jun 23.
The essential roles of thiol compounds as redox signaling mediators and protectors have been established. Recently, the roles of persulfides and polysulfides as mediators involved in numerous physiological processes have been revealed. Recently, it became possible to detect and measure persulfides and polysulfides in human fluids and tissues and their physiological functions, including cellular signaling and protection against oxidative stress, have been reported, but the underlying mechanisms and dynamics remain elusive. Physiological functions of thiol compounds have been studied, focusing primarily on two-electron redox reactions. In contrast, the contribution of one-electron redox mechanisms, that is, free radical-mediated oxidation and antioxidation, has received much less attention. Considering the important effects of free radical-mediated oxidation of biological molecules on pathophysiology, the antioxidant functions of thiol compounds as free radical scavengers are challenging issues. The antioxidant actions and dynamics of thiols, hydropersulfides, and hydropolysulfides as free radical scavenging antioxidants and their physiological significance remain to be established. 39, 728-743.
巯基化合物作为氧化还原信号转导介质和保护剂的基本作用已经确立。最近，发现过硫酸盐和多硫酸盐作为涉及许多生理过程的介质的作用。最近，已经有可能在人体液和组织中检测和测量过硫酸盐和多硫酸盐，并且已经报道了它们的生理功能，包括细胞信号转导和抵抗氧化应激，但潜在的机制和动态仍然难以捉摸。巯基化合物的生理功能已经得到研究，主要集中在两电子氧化还原反应上。相比之下，一电子氧化还原机制的贡献，即自由基介导的氧化和抗氧化作用，受到的关注要少得多。考虑到生物分子自由基介导的氧化对病理生理学的重要影响，作为自由基清除剂的巯基化合物的抗氧化功能是一个具有挑战性的问题。作为自由基清除抗氧化剂的巯基、氢过硫酸盐和氢多硫酸盐的抗氧化作用和动态及其生理意义仍有待确定。39, 728-743。
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