Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland.
Biosci Rep. 2022 Sep 30;42(9). doi: 10.1042/BSR20221006.
Reactive sulfur species (RSS) have been recognized in the last two decades as very important molecules in redox regulation. They are involved in metabolic processes and, in this way, they are responsible for maintenance of health. This review summarizes current information about the essential biological RSS, including H2S, low molecular weight persulfides, protein persulfides as well as organic and inorganic polysulfides, their synthesis, catabolism and chemical reactivity. Moreover, the role of RSS disturbances in various pathologies including vascular diseases, chronic kidney diseases, diabetes mellitus Type 2, neurological diseases, obesity, chronic obstructive pulmonary disease and in the most current problem of COVID-19 is presented. The significance of RSS in aging is also mentioned. Finally, the possibilities of using the precursors of various forms of RSS for therapeutic purposes are discussed.
在过去的二十年中，活性硫物种 (RSS) 已被认为是氧化还原调节中非常重要的分子。它们参与代谢过程，因此负责维持健康。这篇综述总结了有关基本生物 RSS 的最新信息，包括 H2S、低分子量过硫化物、蛋白质过硫化物以及有机和无机多硫化物，它们的合成、分解代谢和化学反应性。此外，还介绍了 RSS 紊乱在各种疾病中的作用，包括血管疾病、慢性肾脏病、2 型糖尿病、神经疾病、肥胖症、慢性阻塞性肺疾病以及当前 COVID-19 最严重的问题。还提到了 RSS 在衰老中的意义。最后，讨论了使用各种形式 RSS 前体进行治疗的可能性。
