Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, China.
Department of Orthopedics, Hengyang Medical School, The First Affiliated Hospital of University of South China, Hengyang, 421001, Hunan, China.
Mol Biotechnol. 2024 Jan;66(1):1-10. doi: 10.1007/s12033-023-00736-9. Epub 2023 May 8.
Osteoarthritis (OA), a chronic degenerative disease characterized mainly by damage to the articular cartilage, is increasingly relevant to the pathological processes of senescence, apoptosis, autophagy, proliferation, and differentiation of chondrocytes. Clinical strategies for osteoarthritis can only improve symptoms and even along with side effects due to age, sex, disease, and other factors. Therefore, there is an urgent need to identify new ideas and targets for current clinical treatment. The tumor suppressor gene p53, which has been identified as a potential target for tumor therapeutic intervention, is responsible for the direct induction of the pathological processes involved in OA modulation. Consequently, deciphering the characteristics of p53 in chondrocytes is essential for investigating OA pathogenesis due to p53 regulation in an array of signaling pathways. This review highlights the effects of p53 on senescence, apoptosis, and autophagy of chondrocytes and its role in the development of OA. It also elucidates the underlying mechanism of p53 regulation in OA, which may help provide a novel strategies for the clinical treatment of OA.
骨关节炎（OA）是一种以关节软骨损伤为主要特征的慢性退行性疾病，它与衰老、细胞凋亡、自噬、软骨细胞增殖和分化等病理过程密切相关。OA 的临床治疗策略只能改善症状，甚至由于年龄、性别、疾病等因素还会带来副作用。因此，迫切需要为当前的临床治疗找到新的思路和靶点。肿瘤抑制基因 p53 已被确定为肿瘤治疗干预的潜在靶点，它负责直接诱导 OA 调节中涉及的病理过程。因此，由于 p53 在一系列信号通路中的调节，研究 OA 发病机制时必须阐明 p53 在软骨细胞中的特征。本综述重点介绍了 p53 对软骨细胞衰老、凋亡和自噬的影响及其在 OA 发生发展中的作用，阐明了 p53 在 OA 中的调控机制，这可能有助于为 OA 的临床治疗提供新策略。
